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XB-PERS-1410
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Name: Evgenia S. Kornikova
Position: Postgraduate student
Research Description:
Influence of the relaxation of mechanical tensions upon collective cell movements, shape formation, and expression patterns of tissue-specific genes has been studied in Xenopus laevis embryos. We show that the local relaxation of tensile stresses within the suprablastoporal area (SBA) performed at the early-midgastrula stage leads to a complete arrest of normal convergent cell intercalation towards the dorsal midline. The antero-posterior and dorso-ventral polarity, as well as expression patterns of pan-neural (Sox3), muscular cardiac actin, and forebrain (Otx2) genes of the dorsally relaxed embryos and SBA explants substantially deviate from the normal ones. The role of tissue tensions in regulating collective cell movements and creating pharyngula-like shapes are discussed.
Contact Information
Address:
Lomonosov Moscow State University
Leninskie gori, 1/12
Moscow
119991, Russia