Pierre D McCrea
Our overall goal is to understand the cellular and developmental functions of catenins. 1) Reveal the roles of additional catenins in the canonical-Wnt pathway, as well as non-canonical Wnt pathways in animal development. 2) Examine the developmental functions of lesser understood catenins such as p120-catenin, ARVCF-catenin and delta-catenin. Aim (2) occupies most of our laboratory's current efforts. For example, we are working upon delta-catenin in the context of shaping neurons/ dendrites, which has implications for both normal development (e.g. brain function) and disease processes.
Lab MembershipsMcCrea Lab (Principal Investigator/Director)
Department of Genetics
U.T. M .D. Anderson Cancer Center
1515 Holcombe Boulevard