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Mucociliary development, regeneration and disease.
The Walentek lab studies the molecular mechanisms of mucociliary development, regeneration and disease. Mucociliary epithelia line the embryonic epidermis as well as the respiratory tract of many animal species, and provide an important first line of defense against pathogens for the organism. We are particularly interested to elucidate the interactions between cell signaling, transcriptional and post-transcriptional regulation of gene regulatory networks, and the morphogenetic processes at the cellular and tissue-wide levels, which facilitate complex tissue formation and function. Our work aims to provide crucial insights into the logic of self-organization in biological systems as well as into the molecular mechanisms underlying chronic lung diseases.