Research Interests

Embryonic endoderm patterning and organogenesis

Research Area

The main focus of the laboratory is to elucidate the mechanisms that pattern the embryonic endoderm in order to generate distinct organs, such as the pancreas and liver. To this aim, we perform comparative studies using both amphibian and mammalian model systems, including mouse embryos and embryonic stem cells. Future aims are directed towards applying developmental regulators of the fate decision between liver and pancreas to lineage reprogramming strategy in order to generate functional pancreatic beta-cells.

Current Members

Spagnoli, Francesca M (Principal Investigator/Director)

Additional Information

Research interest – Pancreas organogenesis; Stem cell analysis to define lineage-specific differentiation towards endodermal tissues, including hepatic and pancreatic lineages; Lineage reprogramming between hepatic and pancreatic lineages; Morphogenesis.

Contact

Institution: Max Delbruk Center for Molecular Medicin

Address:
Centre for Stem Cell & Regenerative Medicine
King’s College London
London
United Kingdom

Web Page: https://www.spagnolilab.org/

General/Lab Phone: +49 30 9406 2553

General/Lab Fax: +49 30 9406 2110