Research Interests

Proteomics

Research Area

The research in our laboratory is focused on four different areas: The development of novel and improved mass spectrometric and proteomic methods for the analysis of complex protein mixtures and the detailed characterization of proteins within these mixtures, including the analysis of post-translational protein modifications and the quantitation of protein abundances. Development of instrument platforms for the detection and identification of disease-markers with special emphasis on pediatric diseases. The use of mass spectrometry to identify mechanisms of cell cycle control during neurogenesis. Development and applications of strategies to solve systems biological questions and problems at the proteome level. To achieve our goals we use proteomic and mass spectrometric technology in addition to biochemistry and molecular biology approaches, cell culture systems and animal models, including the mouse, the rat, and the African clawed frog Xenopus laevis. The lab is equipped with 4 high-end research grade tandem mass spectrometers complemented by various peripherals, wet lab space and a complete (bio)IT infrastructure. The lab is run jointly by Judith A. J. Steen who holds an appointment in the Neurobiology Department of Children's Hospital and Hanno Steen, appointed in the Pathology Department of Children's Hospital. The research lab is closely associated with the Proteomics Center @ Children's Hospital Boston that offers various services to the researchers within Children's Hospital and the outside research community.

Current Members

Steen, Hanno (Principal Investigator/Director)

Additional Information

For further inquiries, please visit the webpage of the Proteomics Center:

Contact

Institution: Boston Children's Hospital, Harvard

Address:
Boston Children's Hospital
320 Longwood Avenue
Boston, MA
02115, USA

Web Page: http://www.childrenshospital.org/research/centers-departmental-programs/proteomics-center