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Stoichiometry of altered hERG1 channel gating by small molecule activators. , Wu W., J Gen Physiol. April 1, 2014; 143 (4): 499-512.
Blocking of the human ether-à- go-go-related gene channel by imatinib mesylate. , Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.
A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. , Peigneur S., FASEB J. December 1, 2012; 26 (12): 5141-51.
Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule. , Garg V., J Gen Physiol. September 1, 2012; 140 (3): 307-24.
Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A. , Kulzer M., Biochem Biophys Res Commun. July 27, 2012; 424 (2): 315-20.
18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels. , Du YM., Acta Pharmacol Sin. June 1, 2012; 33 (6): 752-60.
A molecular switch driving inactivation in the cardiac K+ channel HERG. , Köpfer DA., PLoS One. January 1, 2012; 7 (7): e41023.
Molecular determinants for activation of human ether-à- go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide. , Garg V., Mol Pharmacol. October 1, 2011; 80 (4): 630-7.
Effects of the histamine H(1) receptor antagonist hydroxyzine on hERG K(+) channels and cardiac action potential duration. , Lee BH., Acta Pharmacol Sin. September 1, 2011; 32 (9): 1128-37.
A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties. , Peigneur S., Biochem Pharmacol. July 1, 2011; 82 (1): 81-90.
A potent potassium channel blocker from Mesobuthus eupeus scorpion venom. , Gao B., Biochimie. December 1, 2010; 92 (12): 1847-53.
Aconitine blocks HERG and Kv1.5 potassium channels. , Li Y., J Ethnopharmacol. August 19, 2010; 131 (1): 187-95.
Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. , Obers S., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2010; 381 (5): 385-400.
Block of the human ether-a- go-go-related gene ( hERG) K+ channel by the antidepressant desipramine. , Hong HK., Biochem Biophys Res Commun. April 9, 2010; 394 (3): 536-41.
Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652. , Xing J., Eur J Pharmacol. March 25, 2010; 630 (1-3): 1-9.
H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. , Jo SH., Pharmacol Res. November 1, 2009; 60 (5): 429-37.
Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine. , Hong HK., Korean J Physiol Pharmacol. June 1, 2009; 13 (3): 215-20.
Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro. , Fanoe S., Br J Clin Pharmacol. February 1, 2009; 67 (2): 172-9.
Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. , Scherer D., Br J Pharmacol. January 1, 2009; 156 (2): 226-36.
Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin. , Scherer D., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2008; 378 (1): 73-83.
Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels. , Cuypers E., Toxicon. May 1, 2008; 51 (6): 974-83.
An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. , Ma Z., J Gen Physiol. May 1, 2008; 131 (5): 483-502.
Modulation of voltage-gated Na+ and K+ channels by pumiliotoxin 251D: a "joint venture" alkaloid from arthropods and amphibians. , Vandendriessche T., Toxicon. March 1, 2008; 51 (3): 334-44.
Protriptyline block of the human ether-à- go-go-related gene ( HERG) K+ channel. , Jo SH., Life Sci. January 30, 2008; 82 (5-6): 331-40.
Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide. , Lin C., Cardiology. January 1, 2008; 110 (3): 209-16.
The additive effects of the active component of grapefruit juice (naringenin) and antiarrhythmic drugs on HERG inhibition. , Lin C., Cardiology. January 1, 2008; 110 (3): 145-52.
Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656. , Scholz EP., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2007; 376 (4): 275-84.
Verapamil blocks HERG channel by the helix residue Y652 and F656 in the S6 transmembrane domain. , Duan JJ., Acta Pharmacol Sin. July 1, 2007; 28 (7): 959-67.
Modulation of ERG channels by XE991. , Elmedyb P., Basic Clin Pharmacol Toxicol. May 1, 2007; 100 (5): 316-22.
The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents. , Lin C., Cardiology. January 1, 2007; 108 (1): 18-27.
In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform. , Scholz EP., Toxicol Lett. August 20, 2006; 165 (2): 156-66.
Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels. , Kiesecker C., Naunyn Schmiedebergs Arch Pharmacol. June 1, 2006; 373 (3): 212-20.
Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine. , Lee SY., Br J Pharmacol. June 1, 2006; 148 (4): 499-509.
Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs. , Perry M ., Mol Pharmacol. February 1, 2006; 69 (2): 509-19.
Block of hERG channel by ziprasidone: biophysical properties and molecular determinants. , Su Z., Biochem Pharmacol. January 12, 2006; 71 (3): 278-86.
Inhibition of human ether-a- go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine. , Choi SY., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.
Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. , Kiesecker C., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 423-35.
Block of wild-type and inactivation-deficient human ether-a- go-go-related gene K+ channels by halofantrine. , Sánchez-Chapula JA., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 484-91.
Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels. , Gögelein H., Naunyn Schmiedebergs Arch Pharmacol. September 1, 2004; 370 (3): 183-92.
Inhibition of human ether-a- go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. , Thomas D., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.
Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine. , Scholz EP., Naunyn Schmiedebergs Arch Pharmacol. November 1, 2003; 368 (5): 404-14.
Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen. , Thomas D., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2003; 368 (1): 41-8.
The antipsychotic drug chlorpromazine inhibits HERG potassium channels. , Thomas D., Br J Pharmacol. June 1, 2003; 139 (3): 567-74.
Voltage-dependent profile of human ether-a- go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain. , Sănchez-Chapula JA., Mol Pharmacol. May 1, 2003; 63 (5): 1051-8.
Dissociation of E-4031 from the HERG channel caused by mutations of an amino acid results in greater block at high stimulation frequency. , Ishii K., Cardiovasc Res. March 1, 2003; 57 (3): 651-9.
Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. , Gessner G., Br J Pharmacol. January 1, 2003; 138 (1): 161-71.
Structural and functional role of the extracellular s5-p linker in the HERG potassium channel. , Liu J ., J Gen Physiol. November 1, 2002; 120 (5): 723-37.
Bertosamil blocks HERG potassium channels in their open and inactivated states. , Zitron E., Br J Pharmacol. September 1, 2002; 137 (2): 221-8.
Molecular determinants of voltage-dependent human ether-a- go-go related gene ( HERG) K+ channel block. , Sánchez-Chapula JA., J Biol Chem. June 28, 2002; 277 (26): 23587-95.
Inhibition of cardiac potassium currents by pentobarbital. , Bachmann A., Naunyn Schmiedebergs Arch Pharmacol. January 1, 2002; 365 (1): 29-37.