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The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms. , Wang ZJ., J Biol Chem. June 12, 2020; 295 (24): 8164-8173.
The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. , Silbernagel N., FASEB J. November 1, 2018; 32 (11): 6159-6173.
Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family. , Alvarez-Baron CP., J Gen Physiol. August 6, 2018; 150 (8): 1203-1213.
Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK. , Schmidpeter PAM., J Gen Physiol. June 4, 2018; 150 (6): 821-834.
Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation. , Mesirca P., Nat Commun. August 21, 2014; 5 4664.
Local anesthetic inhibits hyperpolarization-activated cationic currents. , Meng QT., Mol Pharmacol. May 1, 2011; 79 (5): 866-73.
Tanshinone IIA selectively enhances hyperpolarization-activated cyclic nucleotide-modulated (HCN) channel instantaneous current. , Liang Q., J Pharmacol Sci. July 1, 2009; 110 (3): 381-8.
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes. , Zhang Q ., Biochim Biophys Acta. May 1, 2009; 1788 (5): 1138-47.
Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. , Cheng L., J Pharmacol Exp Ther. September 1, 2007; 322 (3): 931-9.
Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. , Elinder F., J Physiol. September 1, 2006; 575 (Pt 2): 417-31.
Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. , Cacheaux LP., J Pharmacol Exp Ther. November 1, 2005; 315 (2): 517-25.
Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties. , Männikkö R., J Gen Physiol. March 1, 2005; 125 (3): 305-26.
S4 movement in a mammalian HCN channel. , Vemana S., J Gen Physiol. January 1, 2004; 123 (1): 21-32.
Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels. , Yu HG., Pflugers Arch. January 1, 2004; 447 (4): 392-400.
KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents. , Decher N., Pflugers Arch. September 1, 2003; 446 (6): 633-40.
Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions. , Wang J ., J Gen Physiol. September 1, 2001; 118 (3): 237-50.
Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide. , Chen S., J Gen Physiol. May 1, 2001; 117 (5): 491-504.