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Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues. , Bohannon BM., Elife. June 23, 2023; 12
Functional Characterization of a Spectrum of Novel Romano-Ward Syndrome KCNQ1 Variants. , Rinné S., Int J Mol Sci. January 10, 2023; 24 (2):
Optimized tight binding between the S1 segment and KCNE3 is required for the constitutively open nature of the KCNQ1- KCNE3 channel complex. , Kasuya G., Elife. November 4, 2022; 11
Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels. , Zou X., Front Physiol. January 1, 2022; 13 902224.
The Amyloid Precursor Protein C99 Fragment Modulates Voltage-Gated Potassium Channels. , Manville RW., Cell Physiol Biochem. July 28, 2021; 55 (S3): 157-170.
Molecular Mechanism of Autosomal Recessive Long QT-Syndrome 1 without Deafness. , Oertli A., Int J Mol Sci. January 23, 2021; 22 (3):
Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms. , Bohannon BM., Elife. March 24, 2020; 9
Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state. , Taylor KC., Elife. February 25, 2020; 9
KCNQ1 rescues TMC1 plasma membrane expression but not mechanosensitive channel activity. , Harkcom WT., J Cell Physiol. August 1, 2019; 234 (8): 13361-13369.
ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling. , Hou P., Elife. July 22, 2019; 8
Probing the Dynamics and Structural Topology of the Reconstituted Human KCNQ1 Voltage Sensor Domain (Q1-VSD) in Lipid Bilayers Using Electron Paramagnetic Resonance Spectroscopy. , Dixit G., Biochemistry. February 19, 2019; 58 (7): 965-973.
Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation. , De Silva AM., Sci Adv. November 14, 2018; 4 (11): eaav0824.
KCNE1 tunes the sensitivity of KV7.1 to polyunsaturated fatty acids by moving turret residues close to the binding site. , Larsson JE., Elife. July 17, 2018; 7
Direct neurotransmitter activation of voltage-gated potassium channels. , Manville RW., Nat Commun. May 10, 2018; 9 (1): 1847.
KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions. , Barro-Soria R., Proc Natl Acad Sci U S A. August 29, 2017; 114 (35): E7367-E7376.
KCNE1 induces fenestration in the Kv7.1/ KCNE1 channel complex that allows for highly specific pharmacological targeting. , Wrobel E., Nat Commun. October 12, 2016; 7 12795.
Polyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel. , Liin SI., Proc Natl Acad Sci U S A. May 5, 2015; 112 (18): 5714-9.
High incidence of functional ion-channel abnormalities in a consecutive Long QT cohort with novel missense genetic variants of unknown significance. , Steffensen AB., Sci Rep. January 12, 2015; 5 10009.
Regulation of Voltage Gated K+ Channel KCNE1/ KCNQ1 by the Janus Kinase JAK3. , Warsi J., Cell Physiol Biochem. January 1, 2015; 37 (6): 2476-85.
Ginseng gintonin activates the human cardiac delayed rectifier K+ channel: involvement of Ca2+/calmodulin binding sites. , Choi SH., Mol Cells. September 1, 2014; 37 (9): 656-63.
Functional assembly of Kv7.1/ Kv7.5 channels with emerging properties on vascular muscle physiology. , Oliveras A., Arterioscler Thromb Vasc Biol. July 1, 2014; 34 (7): 1522-30.
Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel. , Zaydman MA., Elife. March 12, 2014; 3 e03606.
Upregulation of KCNQ1/ KCNE1 K+ channels by Klotho. , Almilaji A., Channels (Austin). January 1, 2014; 8 (3): 222-9.
Inhibition of ROMK channels by low extracellular K+ and oxidative stress. , Frindt G., Am J Physiol Renal Physiol. July 15, 2013; 305 (2): F208-15.
Differential effects of ginsenoside metabolites on slowly activating delayed rectifier K(+) and KCNQ1 K(+) channel currents. , Choi SH., J Ginseng Res. July 1, 2013; 37 (3): 324-31.
Role of the Rap2/ TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling. , Park DS., Biochem Biophys Res Commun. June 28, 2013; 436 (2): 338-43.
Purinergic signalling - a possible mechanism for KCNQ1 channel response to cell volume challenges. , Hammami S., Acta Physiol (Oxf). March 1, 2013; 207 (3): 503-15.
Impaired ion channel function related to a common KCNQ1 mutation - implications for risk stratification in long QT syndrome 1. , Aidery P., Gene. December 10, 2012; 511 (1): 26-33.
AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation. , Föller M., FASEB J. October 1, 2012; 26 (10): 4243-53.
Deubiquitylating enzyme USP2 counteracts Nedd4-2-mediated downregulation of KCNQ1 potassium channels. , Krzystanek K., Heart Rhythm. March 1, 2012; 9 (3): 440-8.
Involvement of the eukaryotic initiation factor 6 and kermit2/ gipc2 in Xenopus laevis pronephros formation. , Tussellino M., Int J Dev Biol. January 1, 2012; 56 (5): 357-62.
Agonistic and antagonistic roles for TNIK and MINK in non-canonical and canonical Wnt signalling. , Mikryukov A., PLoS One. January 1, 2012; 7 (9): e43330.
Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environments. , Coey AT., Biochemistry. December 20, 2011; 50 (50): 10851-9.
KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue. , Nakajo K., J Gen Physiol. November 1, 2011; 138 (5): 521-35.
Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state. , Larsen AP., Biophys J. August 17, 2011; 101 (4): 818-27.
Inhibition of the heterotetrameric K+ channel KCNQ1/ KCNE1 by the AMP-activated protein kinase. , Alesutan I., Mol Membr Biol. February 1, 2011; 28 (2): 79-89.
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway. , Blackiston D ., Dis Model Mech. January 1, 2011; 4 (1): 67-85.
A shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensor. , Choi E., FASEB J. May 1, 2010; 24 (5): 1518-24.
KCNE1 and KCNE3 beta-subunits regulate membrane surface expression of Kv12.2 K(+) channels in vitro and form a tripartite complex in vivo. , Clancy SM., PLoS One. July 22, 2009; 4 (7): e6330.
Discovery of a novel activator of KCNQ1- KCNE1 K channel complexes. , Mruk K., PLoS One. January 1, 2009; 4 (1): e4236.
Functional implications of KCNE subunit expression for the Kv7.5 ( KCNQ5) channel. , Roura-Ferrer M., Cell Physiol Biochem. January 1, 2009; 24 (5-6): 325-34.
Modulation of potassium channel function confers a hyperproliferative invasive phenotype on embryonic stem cells. , Morokuma J., Proc Natl Acad Sci U S A. October 28, 2008; 105 (43): 16608-13.
KCNE1 constrains the voltage sensor of Kv7.1 K+ channels. , Shamgar L., PLoS One. April 9, 2008; 3 (4): e1943.
Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes. , Morin TJ., Proc Natl Acad Sci U S A. February 5, 2008; 105 (5): 1478-82.
KCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channels. , Rocheleau JM., J Gen Physiol. January 1, 2008; 131 (1): 59-68.
KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel. , Nakajo K., J Gen Physiol. September 1, 2007; 130 (3): 269-81.
Chromanol 293B binding in KCNQ1 ( Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter. , Lerche C., Mol Pharmacol. June 1, 2007; 71 (6): 1503-11.
Regulation of endocytic recycling of KCNQ1/ KCNE1 potassium channels. , Seebohm G ., Circ Res. March 16, 2007; 100 (5): 686-92.
The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes. , Panaghie G., J Gen Physiol. February 1, 2007; 129 (2): 121-33.
Secondary structure of a KCNE cytoplasmic domain. , Rocheleau JM., J Gen Physiol. December 1, 2006; 128 (6): 721-9.