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Summary Anatomy Item Literature (785) Expression Attributions Wiki
XB-ANAT-9

Papers associated with lens (and gja8)

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Molecular mechanisms underlying enhanced hemichannel function of a cataract-associated Cx50 mutant., Tong JJ., Biophys J. December 21, 2021; 120 (24): 5644-5656.


Modeling ocular lens disease in Xenopus., Viet J., Dev Dyn. May 1, 2020; 249 (5): 610-621.          


The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating., Tong JJ., J Membr Biol. February 1, 2015; 248 (1): 145-55.                


Connexin 46 (cx46) gap junctions provide a pathway for the delivery of glutathione to the lens nucleus., Slavi N., J Biol Chem. November 21, 2014; 289 (47): 32694-702.


Functional characterization of an AQP0 missense mutation, R33C, that causes dominant congenital lens cataract, reveals impaired cell-to-cell adhesion., Kumari SS., Exp Eye Res. November 1, 2013; 116 371-85.                  


Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46., Tong JJ., Am J Physiol Cell Physiol. May 1, 2013; 304 (9): C823-32.


Cataract-associated D3Y mutation of human connexin46 (hCx46) increases the dye coupling of gap junction channels and suppresses the voltage sensitivity of hemichannels., Schlingmann B., J Bioenerg Biomembr. October 1, 2012; 44 (5): 607-14.


Cataracts and microphthalmia caused by a Gja8 mutation in extracellular loop 2., Xia CH., PLoS One. January 1, 2012; 7 (12): e52894.          


Different consequences of cataract-associated mutations at adjacent positions in the first extracellular boundary of connexin50., Tong JJ., Am J Physiol Cell Physiol. May 1, 2011; 300 (5): C1055-64.


Properties of connexin 46 hemichannels in dissociated lens fiber cells., Ebihara L., Invest Ophthalmol Vis Sci. February 1, 2011; 52 (2): 882-9.


The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation., Graw J., Mol Vis. May 18, 2009; 15 1881-5.      


Interaction between Connexin50 and mitogen-activated protein kinase signaling in lens homeostasis., Shakespeare TI., Mol Biol Cell. May 1, 2009; 20 (10): 2582-92.


The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium., DeRosa AM., Exp Cell Res. April 1, 2009; 315 (6): 1063-75.


Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner., Banks EA., J Cell Sci. February 1, 2009; 122 (Pt 3): 378-88.


A novel connexin50 mutation associated with congenital nuclear pulverulent cataracts., Arora A., J Med Genet. March 1, 2008; 45 (3): 155-60.


The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins., DeRosa AM., J Cell Sci. December 1, 2007; 120 (Pt 23): 4107-16.


Transgenic overexpression of connexin50 induces cataracts., Chung J., Exp Eye Res. March 1, 2007; 84 (3): 513-28.


Functional characterization of a naturally occurring Cx50 truncation., DeRosa AM., Invest Ophthalmol Vis Sci. October 1, 2006; 47 (10): 4474-81.


Regulation of connexin hemichannels by monovalent cations., Srinivas M., J Gen Physiol. January 1, 2006; 127 (1): 67-75.          


Connexins are mechanosensitive., Bao L., Am J Physiol Cell Physiol. November 1, 2004; 287 (5): C1389-95.


Exchange of gating properties between rat cx46 and chicken cx45.6., Tong JJ., Biophys J. October 1, 2004; 87 (4): 2397-406.


Hemichannel and junctional properties of connexin 50., Beahm DL., Biophys J. April 1, 2002; 82 (4): 2016-31.


Inhibition of gap junction hemichannels by chloride channel blockers., Eskandari S., J Membr Biol. January 15, 2002; 185 (2): 93-102.


Co-expression of lens fiber connexins modifies hemi-gap-junctional channel behavior., Ebihara L., Biophys J. January 1, 1999; 76 (1 Pt 1): 198-206.


Spatial differences in gap junction gating in the lens are a consequence of connexin cleavage., Lin JS., Eur J Cell Biol. August 1, 1998; 76 (4): 246-50.


Changes in lens connexin expression lead to increased gap junctional voltage dependence and conductance., Donaldson PJ., Am J Physiol. September 1, 1995; 269 (3 Pt 1): C590-600.


Bovine connexin44, a lens gap junction protein: molecular cloning, immunologic characterization, and functional expression., Gupta VK., Invest Ophthalmol Vis Sci. September 1, 1994; 35 (10): 3747-58.


Selective interactions among the multiple connexin proteins expressed in the vertebrate lens: the second extracellular domain is a determinant of compatibility between connexins., White TW., J Cell Biol. May 1, 1994; 125 (4): 879-92.


Mouse Cx50, a functional member of the connexin family of gap junction proteins, is the lens fiber protein MP70., White TW., Mol Biol Cell. July 1, 1992; 3 (7): 711-20.


Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes., Paul DL., J Cell Biol. November 1, 1991; 115 (4): 1077-89.

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