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Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components. , Hantel F., J Cell Sci. May 1, 2022; 135 (9):
Deep learning is widely applicable to phenotyping embryonic development and disease. , Naert T., Development. November 1, 2021; 148 (21):
Role of KLHL3 and dietary K+ in regulating KS- WNK1 expression. , Ostrosky-Frid M., Am J Physiol Renal Physiol. May 1, 2021; 320 (5): F734-F747.
Structure-function relationships in the renal NaCl cotransporter (NCC). , Moreno E., Curr Top Membr. January 1, 2019; 83 177-204.
Kidney-specific WNK1 isoform (KS- WNK1) is a potent activator of WNK4 and NCC. , Argaiz ER., Am J Physiol Renal Physiol. September 1, 2018; 315 (3): F734-F745.
Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney. , Zhang B., Development. March 22, 2018; 145 (6):
Functional assessment of sodium chloride cotransporter NCC mutants in polarized mammalian epithelial cells. , Rosenbaek LL., Am J Physiol Renal Physiol. August 1, 2017; 313 (2): F495-F504.
Renal localization and regulation by dietary phosphate of the MCT14 orphan transporter. , Knöpfel T., PLoS One. June 29, 2017; 12 (6): e0177942.
Functionomics of NCC mutations in Gitelman syndrome using a novel mammalian cell-based activity assay. , Valdez-Flores MA., Am J Physiol Renal Physiol. December 1, 2016; 311 (6): F1159-F1167.
The European Eel NCCβ Gene Encodes a Thiazide-resistant Na-Cl Cotransporter. , Moreno E., J Biol Chem. October 21, 2016; 291 (43): 22472-22481.
ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation. , Murthy M., Physiol Rep. July 1, 2016; 4 (13):
Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling. , Tutakhel OA., Am J Physiol Renal Physiol. February 1, 2016; 310 (3): F204-16.
Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3. , McCormick JA., J Clin Invest. November 1, 2014; 124 (11): 4723-36.
Sterol carrier protein 2 regulates proximal tubule size in the Xenopus pronephric kidney by modulating lipid rafts. , Cerqueira DM., Dev Biol. October 1, 2014; 394 (1): 54-64.
MicroRNAs are critical regulators of tuberous sclerosis complex and mTORC1 activity in the size control of the Xenopus kidney. , Romaker D., Proc Natl Acad Sci U S A. April 29, 2014; 111 (17): 6335-40.
Regulation of NKCC2 activity by inhibitory SPAK isoforms: KS- SPAK is a more potent inhibitor than SPAK2. , Park HJ., Am J Physiol Renal Physiol. December 15, 2013; 305 (12): F1687-96.
Regulation of G-protein signaling via Gnas is required to regulate proximal tubular growth in the Xenopus pronephros. , Zhang B., Dev Biol. April 1, 2013; 376 (1): 31-42.
Calponin 2 acts as an effector of noncanonical Wnt-mediated cell polarization during neural crest cell migration. , Ulmer B., Cell Rep. March 28, 2013; 3 (3): 615-21.
Insulin increases the functional activity of the renal NaCl cotransporter. , Chávez-Canales M., J Hypertens. February 1, 2013; 31 (2): 303-11.
Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC. , Rosenbaek LL., J Physiol. December 1, 2012; 590 (23): 6121-39.
A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo. , Oi K., Biol Open. February 15, 2012; 1 (2): 120-7.
WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. , Rinehart J., J Biol Chem. August 26, 2011; 286 (34): 30171-80.
Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models. , Liu Z., Hum Mol Genet. March 1, 2011; 20 (5): 855-66.
Inversin relays Frizzled-8 signals to promote proximal pronephros development. , Lienkamp S ., Proc Natl Acad Sci U S A. November 23, 2010; 107 (47): 20388-93.
The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4. , Glover M., Can J Physiol Pharmacol. October 1, 2010; 88 (10): 986-95.
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. , Leviel F., J Clin Invest. May 1, 2010; 120 (5): 1627-35.
The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity. , Tran U ., Development. April 1, 2010; 137 (7): 1107-16.
The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/ Lhx1. , Agrawal R ., Development. December 1, 2009; 136 (23): 3927-36.
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. , Rozansky DJ., J Clin Invest. September 1, 2009; 119 (9): 2601-12.
Renal and brain isoforms of WNK3 have opposite effects on NCCT expression. , Glover M., J Am Soc Nephrol. June 1, 2009; 20 (6): 1314-22.
Renal Na+-K+-Cl- cotransporter activity and vasopressin-induced trafficking are lipid raft-dependent. , Welker P., Am J Physiol Renal Physiol. September 1, 2008; 295 (3): F789-802.
Surface expression of epithelial Na channel protein in rat kidney. , Frindt G., J Gen Physiol. June 1, 2008; 131 (6): 617-27.
Cotransporters, WNKs and hypertension: an update. , Flatman PW., Curr Opin Nephrol Hypertens. March 1, 2008; 17 (2): 186-92.
Organization of the pronephric kidney revealed by large-scale gene expression mapping. , Raciti D ., Genome Biol. January 1, 2008; 9 (5): R84.
Identification and gene expression of versican during early development of Xenopus. , Casini P., Int J Dev Biol. January 1, 2008; 52 (7): 993-8.
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex. , Yang CL., J Clin Invest. November 1, 2007; 117 (11): 3403-11.
Molecular variants of the thiazide-sensitive Na+-Cl- cotransporter in hypertensive families. , Keszei AP., J Hypertens. October 1, 2007; 25 (10): 2074-81.
The prepattern transcription factor Irx3 directs nephron segment identity. , Reggiani L., Genes Dev. September 15, 2007; 21 (18): 2358-70.
Xenopus Bicaudal-C is required for the differentiation of the amphibian pronephros. , Tran U ., Dev Biol. July 1, 2007; 307 (1): 152-64.
WNK4 kinase is a negative regulator of K+-Cl- cotransporters. , Garzón-Muvdi T., Am J Physiol Renal Physiol. April 1, 2007; 292 (4): F1197-207.
An SGK1 site in WNK4 regulates Na+ channel and K+ channel activity and has implications for aldosterone signaling and K+ homeostasis. , Ring AM., Proc Natl Acad Sci U S A. March 6, 2007; 104 (10): 4025-9.
WNK4 enhances TRPV5-mediated calcium transport: potential role in hypercalciuria of familial hyperkalemic hypertension caused by gene mutation of WNK4. , Jiang Y., Am J Physiol Renal Physiol. February 1, 2007; 292 (2): F545-54.
WNK1 affects surface expression of the ROMK potassium channel independent of WNK4. , Cope G., J Am Soc Nephrol. July 1, 2006; 17 (7): 1867-74.
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform. , Subramanya AR., Am J Physiol Renal Physiol. March 1, 2006; 290 (3): F619-24.
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. , Rinehart J., Proc Natl Acad Sci U S A. November 15, 2005; 102 (46): 16777-82.
WNK kinases and the control of blood pressure. , Cope G., Pharmacol Ther. May 1, 2005; 106 (2): 221-31.
[WNK1 and WNK4, new players in salt and water homeostasis] , Hadchouel J., Med Sci (Paris). January 1, 2005; 21 (1): 55-60.
A single nucleotide polymorphism alters the activity of the renal Na+:Cl- cotransporter and reveals a role for transmembrane segment 4 in chloride and thiazide affinity. , Moreno E., J Biol Chem. April 16, 2004; 279 (16): 16553-60.
The structural unit of the thiazide-sensitive NaCl cotransporter is a homodimer. , de Jong JC., J Biol Chem. July 4, 2003; 278 (27): 24302-7.
Interaction with grp58 increases activity of the thiazide-sensitive Na-Cl cotransporter. , Wyse B., Am J Physiol Renal Physiol. March 1, 2002; 282 (3): F424-30.