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Summary Anatomy Item Literature (4906) Expression Attributions Wiki
XB-ANAT-3713

Papers associated with left (and lefty)

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Embryonic asymmetry: left TGFbeta at the right time?, King T., Curr Biol. April 1, 1997; 7 (4): R212-5.


Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos., Meno C., Genes Cells. August 1, 1997; 2 (8): 513-24.    


Molecular mechanisms of vertebrate left-right development., Ramsdell AF., Trends Genet. November 1, 1998; 14 (11): 459-65.


Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis., Chazaud C., Development. June 1, 1999; 126 (12): 2589-96.


The SIL gene is required for mouse embryonic axial development and left-right specification., Izraeli S., Nature. June 17, 1999; 399 (6737): 691-4.


Antagonistic signaling by Caronte, a novel Cerberus-related gene, establishes left-right asymmetric gene expression., Yokouchi Y., Cell. September 3, 1999; 98 (5): 573-83.


The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry., Rodríguez Esteban C., Nature. September 16, 1999; 401 (6750): 243-51.


Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms., Essner JJ., Development. March 1, 2000; 127 (5): 1081-93.      


The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in xenopus., Cheng AM., Development. March 1, 2000; 127 (5): 1049-61.                


Mechanisms of left-right determination in vertebrates., Capdevila J., Cell. March 31, 2000; 101 (1): 9-21.          


The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination., Murcia NS., Development. June 1, 2000; 127 (11): 2347-55.


Regulation of gut and heart left-right asymmetry by context-dependent interactions between xenopus lefty and BMP4 signaling., Branford WW., Dev Biol. July 15, 2000; 223 (2): 291-306.              


Expression cloning of Xantivin, a Xenopus lefty/antivin-related gene, involved in the regulation of activin signaling during mesoderm induction., Tanegashima K., Mech Dev. December 1, 2000; 99 (1-2): 3-14.  


Dickkopf1 and the Spemann-Mangold head organizer., Niehrs C., Int J Dev Biol. January 1, 2001; 45 (1): 237-40.    


The pitx2 homeobox protein is required early for endoderm formation and nodal signaling. ., Faucourt M., Dev Biol. January 15, 2001; 229 (2): 287-306.                


Timing of endogenous activin-like signals and regional specification of the Xenopus embryo., Lee MA., Development. August 1, 2001; 128 (15): 2939-52.            


Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor., Kramer KL., Dev Cell. January 1, 2002; 2 (1): 115-24.  


Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning., Levin M., Cell. October 4, 2002; 111 (1): 77-89.              


Lefty-dependent inhibition of Nodal- and Wnt-responsive organizer gene expression is essential for normal gastrulation., Branford WW., Curr Biol. December 23, 2002; 12 (24): 2136-41.              


PKCgamma regulates syndecan-2 inside-out signaling during xenopus left-right development., Kramer KL., Cell. December 27, 2002; 111 (7): 981-90.                


Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-beta5 protein., Mogi K., Int J Dev Biol. February 1, 2003; 47 (1): 15-29.                  


Regulation of nodal and BMP signaling by tomoregulin-1 (X7365) through novel mechanisms., Chang C., Dev Biol. March 1, 2003; 255 (1): 1-11.                    


Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality., Concha ML., Neuron. July 31, 2003; 39 (3): 423-38.


Lefty blocks a subset of TGFbeta signals by antagonizing EGF-CFC coreceptors., Cheng SK., PLoS Biol. February 1, 2004; 2 (2): E30.                  


The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish., Hashimoto H., Development. April 1, 2004; 131 (8): 1741-53.


Two modes by which Lefty proteins inhibit nodal signaling., Chen C., Curr Biol. April 6, 2004; 14 (7): 618-24.


Xenopus nodal related-1 is indispensable only for left-right axis determination., Toyoizumi R., Int J Dev Biol. January 1, 2005; 49 (8): 923-38.                


Exploration of the extracellular space by a large-scale secretion screen in the early Xenopus embryo., Pera EM., Int J Dev Biol. January 1, 2005; 49 (7): 781-96.                                  


Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos., Fukumoto T., Curr Biol. May 10, 2005; 15 (9): 794-803.      


Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis., Bisgrove BW., Dev Biol. November 15, 2005; 287 (2): 274-88.


The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo., Chen C., Development. January 1, 2006; 133 (2): 319-29.              


XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning., Onuma Y., Development. January 1, 2006; 133 (2): 237-50.                                      


Cooperative non-cell and cell autonomous regulation of Nodal gene expression and signaling by Lefty/Antivin and Brachyury in Xenopus., Cha YR., Dev Biol. February 15, 2006; 290 (2): 246-64.                        


Nodal-related gene Xnr5 is amplified in the Xenopus genome., Takahashi S., Genesis. July 1, 2006; 44 (7): 309-21.          


Formation of the ascidian epidermal sensory neurons: insights into the origin of the chordate peripheral nervous system., Pasini A., PLoS Biol. July 1, 2006; 4 (7): e225.              


Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo., Ho DM., Dev Biol. July 15, 2006; 295 (2): 730-42.            


Subtilisin-like proprotein convertase activity is necessary for left-right axis determination in Xenopus neurula embryos., Toyoizumi R., Dev Genes Evol. October 1, 2006; 216 (10): 607-22.


Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides., Rana AA., PLoS Genet. November 17, 2006; 2 (11): e193.                                    


Anteriorward shifting of asymmetric Xnr1 expression and contralateral communication in left-right specification in Xenopus., Ohi Y., Dev Biol. January 15, 2007; 301 (2): 447-63.


The left-right axis is regulated by the interplay of Coco, Xnr1 and derrière in Xenopus embryos., Vonica A., Dev Biol. March 1, 2007; 303 (1): 281-94.              


Evolution of axis specification mechanisms in jawed vertebrates: insights from a chondrichthyan., Coolen M., PLoS One. April 18, 2007; 2 (4): e374.              


Long-range action of Nodal requires interaction with GDF1., Tanaka C., Genes Dev. December 15, 2007; 21 (24): 3272-82.        


The miR-430/427/302 family controls mesendodermal fate specification via species-specific target selection., Rosa A., Dev Cell. April 1, 2009; 16 (4): 517-27.    


Distinct Xenopus Nodal ligands sequentially induce mesendoderm and control gastrulation movements in parallel to the Wnt/PCP pathway., Luxardi G., Development. February 1, 2010; 137 (3): 417-26.          


APOBEC2, a selective inhibitor of TGFβ signaling, regulates left-right axis specification during early embryogenesis., Vonica A., Dev Biol. February 1, 2011; 350 (1): 13-23.                


Rapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in Xenopus., Marjoram L., Development. February 1, 2011; 138 (3): 475-85.            


Essential roles of fibronectin in the development of the left-right embryonic body plan., Pulina MV., Dev Biol. June 15, 2011; 354 (2): 208-20.


HEB and E2A function as SMAD/FOXH1 cofactors., Yoon SJ., Genes Dev. August 1, 2011; 25 (15): 1654-61.            


Laterality defects are influenced by timing of treatments and animal model., Vandenberg LN., Differentiation. January 1, 2012; 83 (1): 26-37.          


Neurally Derived Tissues in Xenopus laevis Embryos Exhibit a Consistent Bioelectrical Left-Right Asymmetry., Pai VP., Stem Cells Int. January 1, 2012; 2012 353491.          

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