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Summary Anatomy Item Literature (2366) Expression Attributions Wiki

Papers associated with heart (and kcnh1)

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Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current., London B., Circ Res. November 1, 1997; 81 (5): 870-8.

herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?, Bianchi L., Cancer Res. February 15, 1998; 58 (4): 815-22.

Voltage-dependent blockade of HERG channels expressed in Xenopus oocytes by external Ca2+ and Mg2+., Ho WK., J Physiol. March 15, 1998; 507 ( Pt 3) (Pt 3): 631-8.

Functional analysis of a mouse brain Elk-type K+ channel., Trudeau MC., J Neurosci. April 15, 1999; 19 (8): 2906-18.

Preclinical pharmacology of desloratadine, a selective and nonsedating histamine H1 receptor antagonist. 2nd communication: lack of central nervous system and cardiovascular effects., Kreutner W., Arzneimittelforschung. May 1, 2000; 50 (5): 441-8.

Inhibitory effects of berberine on IK1, IK, and HERG channels of cardiac myocytes., Li BX., Acta Pharmacol Sin. February 1, 2001; 22 (2): 125-31.

Antiarrhythmic drug carvedilol inhibits HERG potassium channels., Karle CA., Cardiovasc Res. February 1, 2001; 49 (2): 361-70.

High-affinity blockade of human ether-a-go-go-related gene human cardiac potassium channels by the novel antiarrhythmic drug BRL-32872., Thomas D., J Pharmacol Exp Ther. May 1, 2001; 297 (2): 753-61.

Cloning and functional characterization of the smooth muscle ether-a-go-go-related gene K+ channel. Potential role of a conserved amino acid substitution in the S4 region., Shoeb F., J Biol Chem. January 24, 2003; 278 (4): 2503-14.

Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin., Thomas D., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2004; 369 (5): 462-72.

Block of wild-type and inactivation-deficient human ether-a-go-go-related gene K+ channels by halofantrine., Sánchez-Chapula JA., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2004; 370 (6): 484-91.

Activation of cardiac human ether-a-go-go related gene potassium currents is regulated by alpha(1A)-adrenoceptors., Thomas D., J Mol Med (Berl). December 1, 2004; 82 (12): 826-37.

Inhibition of human ether-a-go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine., Choi SY., J Pharmacol Exp Ther. May 1, 2005; 313 (2): 888-95.

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)., Hansen RS., Mol Pharmacol. January 1, 2006; 69 (1): 266-77.

Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine., Lee SY., Br J Pharmacol. June 1, 2006; 148 (4): 499-509.

Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization., Schwoerer AP., Anesthesiology. May 1, 2007; 106 (5): 967-76.

Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T., J Biol Chem. November 11, 2011; 286 (45): 39091-9.

Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.            

Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel., Park MH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.

Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243., Wu W., Mol Pharmacol. January 1, 2015; 87 (3): 401-9.

Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.                

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