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Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel. , Chapman ML., Pflugers Arch. March 1, 2006; 451 (6): 776-92.
Access of quaternary ammonium blockers to the internal pore of cyclic nucleotide-gated channels: implications for the location of the gate. , Contreras JE., J Gen Physiol. May 1, 2006; 127 (5): 481-94.
Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics. , Zhang Y ., J Gen Physiol. August 1, 2006; 128 (2): 185-202.
Ouabain affinity determining residues lie close to the Na/K pump ion pathway. , Artigas P., Proc Natl Acad Sci U S A. August 15, 2006; 103 (33): 12613-8.
Ion permeation through the Na+,K+-ATPase. , Reyes N., Nature. September 28, 2006; 443 (7110): 470-4.
A conserved ring of charge in mammalian Na+ channels: a molecular regulator of the outer pore conformation during slow inactivation. , Xiong W., J Physiol. November 1, 2006; 576 (Pt 3): 739-54.
NR3A modulates the outer vestibule of the "NMDA" receptor channel. , Wada A., J Neurosci. December 20, 2006; 26 (51): 13156-66.
Cyclophane and acyclic cyclophane: novel channel blockers of N-methyl-D-aspartate receptor. , Masuko T., Neurochem Int. January 1, 2007; 50 (2): 443-9.
A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. , Manolescu AR., Mol Membr Biol. January 1, 2007; 24 (5-6): 455-63.
Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule. , Choudhary G., Channels (Austin). January 1, 2007; 1 (5): 344-52.
A cation-pi interaction discriminates among sodium channels that are either sensitive or resistant to tetrodotoxin block. , Santarelli VP., J Biol Chem. March 16, 2007; 282 (11): 8044-51.
Structural determinants of the closed KCa3.1 channel pore in relation to channel gating: results from a substituted cysteine accessibility analysis. , Klein H., J Gen Physiol. April 1, 2007; 129 (4): 299-315.
Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling. , Tseng GN., Biophys J. May 15, 2007; 92 (10): 3524-40.
Chromanol 293B binding in KCNQ1 ( Kv7.1) channels involves electrostatic interactions with a potassium ion in the selectivity filter. , Lerche C., Mol Pharmacol. June 1, 2007; 71 (6): 1503-11.
Voltage-independent sodium-binding events reported by the 4B-4C loop in the human glutamate transporter excitatory amino acid transporter 3. , Koch HP., J Biol Chem. August 24, 2007; 282 (34): 24547-53.
Cleft-type cyclophanes confer neuroprotection against excitatory neurotoxicity in vitro and in vivo through inhibition of NMDA receptors. , Masuko T., Neuropharmacology. September 1, 2007; 53 (4): 515-23.
Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door? , Szendroedi J., Biophys J. December 15, 2007; 93 (12): 4209-24.
Intrinsic electrostatic potential in the BK channel pore: role in determining single channel conductance and block. , Carvacho I., J Gen Physiol. February 1, 2008; 131 (2): 147-61.
Mutations at arginine 352 alter the pore architecture of CFTR. , Cui G., J Membr Biol. March 1, 2008; 222 (2): 91-106.
Molecular determinants of the anticonvulsant felbamate binding site in the N-methyl-D-aspartate receptor. , Chang HR., J Med Chem. March 27, 2008; 51 (6): 1534-45.
Probing the binding sites and mechanisms of action of two human ether-a- go-go-related gene channel activators, 1,3- bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243). , Xu X., Mol Pharmacol. June 1, 2008; 73 (6): 1709-21.
Differential effects of linear and cyclic polyamines on NMDA receptor activities. , Masuko T., Neurochem Int. July 1, 2008; 53 (1-2): 38-44.
Is TEA an inhibitor for human Aquaporin-1? , Müller EM., Pflugers Arch. July 1, 2008; 456 (4): 663-9.
The ion pathway through the opened Na(+),K(+)-ATPase pump. , Takeuchi A., Nature. November 20, 2008; 456 (7220): 413-6.
Four Ca2+ ions activate TRPM2 channels by binding in deep crevices near the pore but intracellularly of the gate. , Csanády L., J Gen Physiol. February 1, 2009; 133 (2): 189-203.
K+ binding in the G-loop and water cavity facilitates Ba2+ movement in the Kir2.1 channel. , Chang HK., Biochim Biophys Acta. February 1, 2009; 1788 (2): 500-6.
The analysis of desensitizing CNGA1 channels reveals molecular interactions essential for normal gating. , Mazzolini M., J Gen Physiol. April 1, 2009; 133 (4): 375-86.
The evolutionarily conserved residue A653 plays a key role in HERG channel closing. , Stepanovic SZ., J Physiol. June 1, 2009; 587 (Pt 11): 2555-66.
An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels. , Ahern CA., J Gen Physiol. December 1, 2009; 134 (6): 461-9.
Conformational changes associated with proton-dependent gating of ASIC1a. , Passero CJ., J Biol Chem. December 25, 2009; 284 (52): 36473-36481.
The N terminus of monoamine transporters is a lever required for the action of amphetamines. , Sucic S., J Biol Chem. April 2, 2010; 285 (14): 10924-38.
Cooccupancy of the outer vestibule of voltage-gated sodium channels by micro-conotoxin KIIIA and saxitoxin or tetrodotoxin. , Zhang MM., J Neurophysiol. July 1, 2010; 104 (1): 88-97.
Fast and slow voltage sensor rearrangements during activation gating in Kv1.2 channels detected using tetramethylrhodamine fluorescence. , Horne AJ., J Gen Physiol. July 1, 2010; 136 (1): 83-99.
A pore residue of the KCNQ3 potassium M-channel subunit controls surface expression. , Gómez-Posada JC., J Neurosci. July 7, 2010; 30 (27): 9316-23.
A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel. , Zarrabi T., J Biol Chem. December 10, 2010; 285 (50): 39458-70.
Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels. , Oshima A., J Mol Biol. January 21, 2011; 405 (3): 724-35.
Role of an extracellular loop in determining the stoichiometry of Na+-HCO₃⁻ cotransporters. , Chen LM., J Physiol. February 15, 2011; 589 (Pt 4): 877-90.
In glycine and GABA(A) channels, different subunits contribute asymmetrically to channel conductance via residues in the extracellular domain. , Moroni M., J Biol Chem. April 15, 2011; 286 (15): 13414-22.
Insights into the mechanism of pore opening of acid-sensing ion channel 1a. , Tolino LA., J Biol Chem. May 6, 2011; 286 (18): 16297-307.
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula. , Frahm S., Neuron. May 12, 2011; 70 (3): 522-35.
Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain. , Imbrici P., Am J Physiol Cell Physiol. June 1, 2011; 300 (6): C1314-22.
Contributions of counter-charge in a potassium channel voltage-sensor domain. , Pless SA., Nat Chem Biol. July 24, 2011; 7 (9): 617-23.
Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating. , Allsopp RC., J Biol Chem. August 19, 2011; 286 (33): 29207-17.
5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals. , McKinnon NK., J Gen Physiol. October 1, 2011; 138 (4): 453-66.
Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium. , Rubinos C., J Gen Physiol. January 1, 2012; 139 (1): 69-82.
An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling. , Pérez-Siles G., Biochem J. March 1, 2012; 442 (2): 323-34.
Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel. , Roberts JA., Proc Natl Acad Sci U S A. March 20, 2012; 109 (12): 4663-7.
Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore. , Norimatsu Y., Biochemistry. March 20, 2012; 51 (11): 2199-212.
Contribution of residues in second transmembrane domain of ASIC1a protein to ion selectivity. , Carattino MD., J Biol Chem. April 13, 2012; 287 (16): 12927-34.
Bridging the gap between structure and kinetics of human SGLT1. , Sala-Rabanal M., Am J Physiol Cell Physiol. May 1, 2012; 302 (9): C1293-305.