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Summary Anatomy Item Literature (3729) Expression Attributions Wiki
XB-ANAT-99

Papers associated with cardiovascular system (and kcnh2)

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Tel1/ETV6 specifies blood stem cells through the agency of VEGF signaling., Ciau-Uitz A., Dev Cell. April 20, 2010; 18 (4): 569-78.                


The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism., Gessner G., Eur J Pharmacol. April 25, 2010; 632 (1-3): 52-9.


Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine., Obers S., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2010; 381 (5): 385-400.


Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels., Larsen AP., Br J Pharmacol. October 1, 2010; 161 (3): 614-28.


Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride., Jo SH., Korean J Physiol Pharmacol. October 1, 2010; 14 (5): 305-10.


hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine., Staudacher I., Naunyn Schmiedebergs Arch Pharmacol. February 1, 2011; 383 (2): 119-39.


Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells., Crottès D., J Biol Chem. August 12, 2011; 286 (32): 27947-58.


Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide., Garg V., Mol Pharmacol. October 1, 2011; 80 (4): 630-7.


Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T., J Biol Chem. November 11, 2011; 286 (45): 39091-9.


A molecular switch driving inactivation in the cardiac K+ channel HERG., Köpfer DA., PLoS One. January 1, 2012; 7 (7): e41023.          


Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule., Garg V., J Gen Physiol. September 1, 2012; 140 (3): 307-24.                            


Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.            


Blocking of the human ether-à-go-go-related gene channel by imatinib mesylate., Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.


VEGFA-dependent and -independent pathways synergise to drive Scl expression and initiate programming of the blood stem cell lineage in Xenopus., Ciau-Uitz A., Development. June 1, 2013; 140 (12): 2632-42.                                                                                                                            


Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels., Perry MD., J Gen Physiol. September 1, 2013; 142 (3): 275-88.                    


The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT., Mechakra A., Gene. February 25, 2014; 536 (2): 348-56.            


Stoichiometry of altered hERG1 channel gating by small molecule activators., Wu W., J Gen Physiol. April 1, 2014; 143 (4): 499-512.                  


Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels., Ng CA., J Biol Chem. September 12, 2014; 289 (37): 25822-32.


Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.                


Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium., Pedersen PJ., PLoS One. September 4, 2015; 10 (9): e0138320.                  


Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference., Scherer D., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2017; 390 (7): 701-710.


Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations., Furutani K., J Gen Physiol. February 4, 2019; 151 (2): 214-230.                      


Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG., Vasseur L., Int J Mol Sci. June 28, 2019; 20 (13):           


The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: The role of protein kinase C., Park MH., Mol Cell Endocrinol. August 20, 2019; 494 110488.


Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds., Hull CM., Am J Physiol Regul Integr Comp Physiol. December 1, 2019; 317 (6): R921-R931.


Toward a Structural View of hERG Activation by the Small-Molecule Activator ICA-105574., Zangerl-Plessl EM., J Chem Inf Model. January 27, 2020; 60 (1): 360-371.


The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts., Shi YP., Am J Physiol Heart Circ Physiol. August 1, 2020; 319 (2): H251-H261.


Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;               


The plant-derived alkaloid aloperine prevents ischemia/reperfusion injury-induced sudden cardiac death., Hu Z., FASEB J. July 1, 2023; 37 (7): e22999.

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