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Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor. , Spurny R., Proc Natl Acad Sci U S A. May 12, 2015; 112 (19): E2543-52.
The frog inner ear: picture perfect? , Mason MJ., J Assoc Res Otolaryngol. April 1, 2015; 16 (2): 171-88.
A Single Amino Acid Deletion (ΔF1502) in the S6 Segment of CaV2.1 Domain III Associated with Congenital Ataxia Increases Channel Activity and Promotes Ca2+ Influx. , Bahamonde MI., PLoS One. January 1, 2015; 10 (12): e0146035.
Tracking the molecular evolution of calcium permeability in a nicotinic acetylcholine receptor. , Lipovsek M., Mol Biol Evol. December 1, 2014; 31 (12): 3250-65.
Embryological manipulations in the developing Xenopus inner ear reveal an intrinsic role for Wnt signaling in dorsal- ventral patterning. , Forristall CA ., Dev Dyn. October 1, 2014; 243 (10): 1262-74.
Ion conduction and selectivity in acid-sensing ion channel 1. , Yang L., J Gen Physiol. September 1, 2014; 144 (3): 245-55.
Exploring the structure of the voltage-gated Na+ channel by an engineered drug access pathway to the receptor site for local anesthetics. , Lukacs P., J Biol Chem. August 1, 2014; 289 (31): 21770-81.
Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR. , Cui G., J Gen Physiol. August 1, 2014; 144 (2): 159-79.
NMDA receptor structures reveal subunit arrangement and pore architecture. , Lee CH , Lee CH ., Nature. July 10, 2014; 511 (7508): 191-7.
Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells. , Figueroa VA., Front Cell Neurosci. May 27, 2014; 8 265.
Sp8 regulates inner ear development. , Chung HA., Proc Natl Acad Sci U S A. April 29, 2014; 111 (17): 6329-34.
Purinergic receptor-induced Ca2+ signaling in the neuroepithelium of the vomeronasal organ of larval Xenopus laevis. , Dittrich K., Purinergic Signal. January 1, 2014; 10 (2): 327-36.
Alternative splice isoforms of small conductance calcium-activated SK2 channels differ in molecular interactions and surface levels. , Scholl ES., Channels (Austin). January 1, 2014; 8 (1): 62-75.
Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. , Geng FS., Development. November 1, 2013; 140 (21): 4362-74.
Heme impairs the ball-and-chain inactivation of potassium channels. , Sahoo N., Proc Natl Acad Sci U S A. October 15, 2013; 110 (42): E4036-44.
Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation. , Frey EN., PLoS One. August 12, 2013; 8 (8): e71733.
Alkaline pH block of CLC-K kidney chloride channels mediated by a pore lysine residue. , Gradogna A., Biophys J. July 2, 2013; 105 (1): 80-90.
Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity. , Escobedo N., Development. July 1, 2013; 140 (14): 3008-17.
Implications of aberrant temperature-sensitive glucose transport via the glucose transporter deficiency mutant (GLUT1DS) T295M for the alternate-access and fixed-site transport models. , Cunningham P., J Membr Biol. June 1, 2013; 246 (6): 495-511.
Wnt signaling during cochlear development. , Munnamalai V., Semin Cell Dev Biol. May 1, 2013; 24 (5): 480-9.
Restricted neural plasticity in vestibulospinal pathways after unilateral labyrinthectomy as the origin for scoliotic deformations. , Lambert FM ., J Neurosci. April 17, 2013; 33 (16): 6845-56.
Co-expression of Na(V)β subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins. , Zhang MM., Br J Pharmacol. April 1, 2013; 168 (7): 1597-610.
Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels. , Sauguet L., EMBO J. March 6, 2013; 32 (5): 728-41.
Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore. , Klement G., Biophys J. February 19, 2013; 104 (4): 798-806.
Conserved N-terminal negative charges support optimally efficient N-type inactivation of Kv1 channels. , Prince A., PLoS One. January 1, 2013; 8 (4): e62695.
A conserved pre-block interaction motif regulates potassium channel activation and N-type inactivation. , Pfaffinger PJ., PLoS One. January 1, 2013; 8 (11): e79891.
Effects of ginsenoside Rg3 on α9α10 nicotinic acetylcholine receptor-mediated ion currents. , Lee BH., Biol Pharm Bull. January 1, 2013; 36 (5): 812-8.
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. , Spurny R., Proc Natl Acad Sci U S A. October 30, 2012; 109 (44): E3028-34.
A ring of threonines in the inner vestibule of the pore of CNGA1 channels constitutes a binding site for permeating ions. , Marchesi A., J Physiol. October 15, 2012; 590 (20): 5075-90.
High Ca(2+) permeability of a peptide-gated DEG/ENaC from Hydra. , Dürrnagel S., J Gen Physiol. October 1, 2012; 140 (4): 391-402.
Characterization of a novel somatic KCNJ5 mutation delI157 in an aldosterone-producing adenoma. , Murthy M., J Hypertens. September 1, 2012; 30 (9): 1827-33.
Localization of a site of action for benzofuroindole-induced potentiation of BKCa channels. , Lee BC., Mol Pharmacol. August 1, 2012; 82 (2): 143-55.
Bridging the gap between structure and kinetics of human SGLT1. , Sala-Rabanal M., Am J Physiol Cell Physiol. May 1, 2012; 302 (9): C1293-305.
Contribution of residues in second transmembrane domain of ASIC1a protein to ion selectivity. , Carattino MD., J Biol Chem. April 13, 2012; 287 (16): 12927-34.
Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel. , Roberts JA., Proc Natl Acad Sci U S A. March 20, 2012; 109 (12): 4663-7.
Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore. , Norimatsu Y., Biochemistry. March 20, 2012; 51 (11): 2199-212.
An aspartate residue in the external vestibule of GLYT2 (glycine transporter 2) controls cation access and transport coupling. , Pérez-Siles G., Biochem J. March 1, 2012; 442 (2): 323-34.
Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium. , Rubinos C., J Gen Physiol. January 1, 2012; 139 (1): 69-82.
Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environments. , Coey AT., Biochemistry. December 20, 2011; 50 (50): 10851-9.
5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals. , McKinnon NK., J Gen Physiol. October 1, 2011; 138 (4): 453-66.
Cysteine scanning mutagenesis (residues Glu52-Gly96) of the human P2X1 receptor for ATP: mapping agonist binding and channel gating. , Allsopp RC., J Biol Chem. August 19, 2011; 286 (33): 29207-17.
Contributions of counter-charge in a potassium channel voltage-sensor domain. , Pless SA., Nat Chem Biol. July 24, 2011; 7 (9): 617-23.
Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain. , Imbrici P., Am J Physiol Cell Physiol. June 1, 2011; 300 (6): C1314-22.
Aversion to nicotine is regulated by the balanced activity of β4 and α5 nicotinic receptor subunits in the medial habenula. , Frahm S., Neuron. May 12, 2011; 70 (3): 522-35.
Insights into the mechanism of pore opening of acid-sensing ion channel 1a. , Tolino LA., J Biol Chem. May 6, 2011; 286 (18): 16297-307.
In glycine and GABA(A) channels, different subunits contribute asymmetrically to channel conductance via residues in the extracellular domain. , Moroni M., J Biol Chem. April 15, 2011; 286 (15): 13414-22.
Role of an extracellular loop in determining the stoichiometry of Na+-HCO₃⁻ cotransporters. , Chen LM., J Physiol. February 15, 2011; 589 (Pt 4): 877-90.
Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels. , Oshima A., J Mol Biol. January 21, 2011; 405 (3): 724-35.
A molecular switch between the outer and the inner vestibules of the voltage-gated Na+ channel. , Zarrabi T., J Biol Chem. December 10, 2010; 285 (50): 39458-70.
The R109H variant of fascin-2, a developmentally regulated actin crosslinker in hair-cell stereocilia, underlies early-onset hearing loss of DBA/2J mice. , Shin JB., J Neurosci. July 21, 2010; 30 (29): 9683-94.