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Resection of DNA double-strand breaks activates Mre11- Rad50- Nbs1- and Rad9- Hus1- Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts. , Tatsukawa K., Nucleic Acids Res. April 12, 2024; 52 (6): 3146-3163.
APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response. , Lin Y., Elife. May 22, 2023; 12
MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks. , Montales K., PLoS One. August 2, 2022; 17 (8): e0271905.
The p97 segregase cofactor Ubxn7 facilitates replisome disassembly during S-phase. , Tarcan Z., J Biol Chem. August 1, 2022; 298 (8): 102234.
Delineation of a minimal topoisomerase II binding protein 1 for regulated activation of ATR at DNA double-strand breaks. , Ruis K., J Biol Chem. July 1, 2022; 298 (7): 101992.
Inhibition of DNA replication initiation by silver nanoclusters. , Tao Y., Nucleic Acids Res. May 21, 2021; 49 (9): 5074-5083.
Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system. , Montales K., Sci Rep. January 11, 2021; 11 (1): 467.
Distinct roles of XRCC1 in genome integrity in Xenopus egg extracts. , Cupello S., Biochem J. December 23, 2019; 476 (24): 3791-3804.
RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR. , Lyu K., Cell Cycle. April 1, 2019; 18 (8): 898-913.
Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements. , Deng L., Mol Cell. March 7, 2019; 73 (5): 915-929.e6.
TRAIP is a master regulator of DNA interstrand crosslink repair. , Wu RA., Nature. March 1, 2019; 567 (7747): 267-272.
Methods for Studying DNA Single-Strand Break Repair and Signaling in Xenopus laevis Egg Extracts. , Lin Y., Methods Mol Biol. January 1, 2019; 1999 161-172.
HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome. , Jenness C., Proc Natl Acad Sci U S A. January 30, 2018; 115 (5): E876-E885.
Reversal of DDK-Mediated MCM Phosphorylation by Rif1- PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/ Chk1. , Alver RC., Cell Rep. March 7, 2017; 18 (10): 2508-2520.
APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress. , Wallace BD., Proc Natl Acad Sci U S A. January 10, 2017; 114 (2): 304-309.
Xenopus egg extract to study regulation of genome-wide and locus-specific DNA replication. , Raspelli E., Genesis. January 1, 2017; 55 (1-2):
Replication, checkpoint suppression and structure of centromeric DNA. , Romeo F., Nucleus. November 1, 2016; 7 (6): 540-546.
Mdc1 modulates the interaction between TopBP1 and the MRN complex during DNA damage checkpoint responses. , Choi SH., Biochem Biophys Res Commun. October 7, 2016; 479 (1): 5-11.
Xenopus Mcm10 is a CDK-substrate required for replication fork stability. , Chadha GS., Cell Cycle. August 17, 2016; 15 (16): 2183-2195.
Non-homologous end joining repair in Xenopus egg extract. , Zhu S., Sci Rep. June 21, 2016; 6 27797.
Direct Binding to Replication Protein A (RPA)-coated Single-stranded DNA Allows Recruitment of the ATR Activator TopBP1 to Sites of DNA Damage. , Acevedo J., J Biol Chem. June 17, 2016; 291 (25): 13124-31.
Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression. , Aze A., Nat Cell Biol. June 1, 2016; 18 (6): 684-91.
REV1 is important for the ATR- Chk1 DNA damage response pathway in Xenopus egg extracts. , DeStephanis D., Biochem Biophys Res Commun. May 8, 2015; 460 (3): 609-15.
14-3-3 proteins restrain the Exo1 nuclease to prevent overresection. , Chen X., J Biol Chem. May 8, 2015; 290 (19): 12300-12.
Importin β-dependent nuclear import of TopBP1 in ATR- Chk1 checkpoint in Xenopus egg extracts. , Bai L., Cell Signal. May 1, 2014; 26 (5): 857-67.
DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation. , Bétous R., EMBO J. July 31, 2013; 32 (15): 2172-85.
APE2 is required for ATR- Chk1 checkpoint activation in response to oxidative stress. , Willis J., Proc Natl Acad Sci U S A. June 25, 2013; 110 (26): 10592-7.
The Mre11- Rad50- Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks. , Lee J ., Mol Biol Cell. May 1, 2013; 24 (9): 1343-53.
Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation. , Gambus A., Cell Cycle. April 15, 2013; 12 (8): 1225-32.
A role for the MRN complex in ATR activation via TOPBP1 recruitment. , Duursma AM., Mol Cell. April 11, 2013; 50 (1): 116-22.
SUMO2/3 modification of cyclin E contributes to the control of replication origin firing. , Bonne-Andrea C., Nat Commun. January 1, 2013; 4 1850.
Study of the DNA damage checkpoint using Xenopus egg extracts. , Willis J., J Vis Exp. November 5, 2012; (69): e4449.
Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks. , Lee EM ., DNA Repair (Amst). September 1, 2012; 11 (9): 741-52.
Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase. , Sareen A., Nucleic Acids Res. September 1, 2012; 40 (17): 8425-39.
Role of replication protein A as sensor in activation of the S-phase checkpoint in Xenopus egg extracts. , Recolin B., Nucleic Acids Res. April 1, 2012; 40 (8): 3431-42.
Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts. , Kumar S ., Cell Cycle. March 15, 2012; 11 (6): 1183-94.
Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. , Peterson SE., J Cell Biol. September 5, 2011; 194 (5): 705-20.
Essential roles of Xenopus TRF2 in telomere end protection and replication. , Muraki K., Genes Cells. June 1, 2011; 16 (6): 728-39.
Phosphorylation of Claspin is triggered by the nucleocytoplasmic ratio at the Xenopus laevis midblastula transition. , Gotoh T., Dev Biol. May 15, 2011; 353 (2): 302-8.
Replication-fork stalling and processing at a single psoralen interstrand crosslink in Xenopus egg extracts. , Le Breton C., PLoS One. April 15, 2011; 6 (4): e18554.
A new in vitro system for activating the cell cycle checkpoint. , Wang J ., Cell Cycle. February 1, 2011; 10 (3): 500-6.
CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts. , Ramírez-Lugo JS., Cell Cycle. February 1, 2011; 10 (3): 469-80.
A novel role for greatwall kinase in recovery from DNA damage. , Peng A ., Cell Cycle. November 1, 2010; 9 (21): 4364-9.
Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2-7 complex. , Kundu LR., Nucleic Acids Res. September 1, 2010; 38 (16): 5409-18.
Continued primer synthesis at stalled replication forks contributes to checkpoint activation. , Van C., J Cell Biol. April 19, 2010; 189 (2): 233-46.
Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9- Hus1- Rad1 complex at stalled replication forks. , Lee J , Lee J ., Mol Biol Cell. March 15, 2010; 21 (6): 926-35.
Treslin collaborates with TopBP1 in triggering the initiation of DNA replication. , Kumagai A ., Cell. February 5, 2010; 140 (3): 349-59.
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. , Yoshida K., J Cell Sci. January 15, 2010; 123 (Pt 2): 225-35.
Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase. , Lindsey-Boltz LA., J Biol Chem. November 27, 2009; 284 (48): 33107-14.
The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ ATM pathways. , Sobeck A., J Biol Chem. September 18, 2009; 284 (38): 25560-8.