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Summary Anatomy Item Literature (204) Expression Attributions Wiki
XB-ANAT-197

Papers associated with vestibule

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Ouabain affinity determining residues lie close to the Na/K pump ion pathway., Artigas P., Proc Natl Acad Sci U S A. August 15, 2006; 103 (33): 12613-8.  


Ring of negative charge in BK channels facilitates block by intracellular Mg2+ and polyamines through electrostatics., Zhang Y., J Gen Physiol. August 1, 2006; 128 (2): 185-202.                


Access of quaternary ammonium blockers to the internal pore of cyclic nucleotide-gated channels: implications for the location of the gate., Contreras JE., J Gen Physiol. May 1, 2006; 127 (5): 481-94.                        


Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel., Chapman ML., Pflugers Arch. March 1, 2006; 451 (6): 776-92.


Pharmacology and surface electrostatics of the K channel outer pore vestibule., Quinn CC., J Membr Biol. January 1, 2006; 212 (1): 51-60.              


Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7)., Manolescu A., J Biol Chem. December 30, 2005; 280 (52): 42978-83.


Electrostatics in the cytoplasmic pore produce intrinsic inward rectification in kir2.1 channels., Yeh SH., J Gen Physiol. December 1, 2005; 126 (6): 551-62.                    


An inhibitor of TRPV1 channels isolated from funnel Web spider venom., Kitaguchi T., Biochemistry. November 29, 2005; 44 (47): 15544-9.


Pharmacological implications of two distinct mechanisms of interaction of memantine with N-methyl-D-aspartate-gated channels., Chen HS., J Pharmacol Exp Ther. September 1, 2005; 314 (3): 961-71.


Probing the geometry of the inner vestibule of BK channels with sugars., Brelidze TI., J Gen Physiol. August 1, 2005; 126 (2): 105-21.              


Slow inactivation in voltage gated potassium channels is insensitive to the binding of pore occluding peptide toxins., Oliva C., Biophys J. August 1, 2005; 89 (2): 1009-19.


Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule., Engh AM., J Gen Physiol. June 1, 2005; 125 (6): 601-17.                  


Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters., Koch HP., J Neurosci. February 16, 2005; 25 (7): 1730-6.


A multifunctional aromatic residue in the external pore vestibule of Na+ channels contributes to the local anesthetic receptor., Tsang SY., Mol Pharmacol. February 1, 2005; 67 (2): 424-34.


State-dependent changes in the electrostatic potential in the pore of a GluR channel., Sobolevsky AI., Biophys J. January 1, 2005; 88 (1): 235-42.


A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation., Chang HK., Biophys J. January 1, 2005; 88 (1): 243-54.


Molecular basis of inward rectification: polyamine interaction sites located by combined channel and ligand mutagenesis., Kurata HT., J Gen Physiol. November 1, 2004; 124 (5): 541-54.                


Inhibition of CFTR channels by a peptide toxin of scorpion venom., Fuller MD., Am J Physiol Cell Physiol. November 1, 2004; 287 (5): C1328-41.


Three mechanisms underlie KCNQ2/3 heteromeric potassium M-channel potentiation., Etxeberria A., J Neurosci. October 13, 2004; 24 (41): 9146-52.


Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel., Sandtner W., Mol Pharmacol. September 1, 2004; 66 (3): 648-57.


Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect., Haug T., J Gen Physiol. August 1, 2004; 124 (2): 173-84.              


Anthraquinone polyamines: novel channel blockers to study N-methyl-D-aspartate receptors., Kashiwagi K., J Pharmacol Exp Ther. June 1, 2004; 309 (3): 884-93.


Molecular basis of pH and Ca2+ regulation of aquaporin water permeability., Németh-Cahalan KL., J Gen Physiol. May 1, 2004; 123 (5): 573-80.            


Protons block BK channels by competitive inhibition with K+ and contribute to the limits of unitary currents at high voltages., Brelidze TI., J Gen Physiol. March 1, 2004; 123 (3): 305-19.                


Outer pore topology of the ECaC-TRPV5 channel by cysteine scan mutagenesis., Dodier Y., J Biol Chem. February 20, 2004; 279 (8): 6853-62.


Molecular basis of calcium regulation in connexin-32 hemichannels., Gómez-Hernández JM., Proc Natl Acad Sci U S A. December 23, 2003; 100 (26): 16030-5.


Agonist-induced conformational changes in the extracellular domain of alpha 7 nicotinic acetylcholine receptors., Lyford LK., Mol Pharmacol. September 1, 2003; 64 (3): 650-8.


Gating competence of constitutively open CLC-0 mutants revealed by the interaction with a small organic Inhibitor., Traverso S., J Gen Physiol. September 1, 2003; 122 (3): 295-306.                                  


External TEA block of shaker K+ channels is coupled to the movement of K+ ions within the selectivity filter., Thompson J., J Gen Physiol. August 1, 2003; 122 (2): 239-46.            


A ring of eight conserved negatively charged amino acids doubles the conductance of BK channels and prevents inward rectification., Brelidze TI., Proc Natl Acad Sci U S A. July 22, 2003; 100 (15): 9017-22.


Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action., Nilsson J., Mol Pharmacol. June 1, 2003; 63 (6): 1417-29.


BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1., Zhang M., Biophys J. May 1, 2003; 84 (5): 3022-36.


[K(+)](o)-dependent change in conformation of the HERG1 long QT mutation N629D channel results in partial reversal of the in vitro disease phenotype., Teng GQ., Cardiovasc Res. March 1, 2003; 57 (3): 642-50.


Molecular site of action of the antiarrhythmic drug propafenone at the voltage-operated potassium channel Kv2.1., Madeja M., Mol Pharmacol. March 1, 2003; 63 (3): 547-56.


The link between ion permeation and inactivation gating of Kv4 potassium channels., Shahidullah M., Biophys J. February 1, 2003; 84 (2 Pt 1): 928-41.


Interactions of the C-11 hydroxyl of tetrodotoxin with the sodium channel outer vestibule., Choudhary G., Biophys J. January 1, 2003; 84 (1): 287-94.


Staggering of subunits in NMDAR channels., Sobolevsky AI., Biophys J. December 1, 2002; 83 (6): 3304-14.


DRPEER: a motif in the extracellular vestibule conferring high Ca2+ flux rates in NMDA receptor channels., Watanabe J., J Neurosci. December 1, 2002; 22 (23): 10209-16.


Binding symmetry of extracellular divalent cations to conduction pore studied using tandem dimers of a CNG channel., Kwon RJ., Biochem Biophys Res Commun. November 8, 2002; 298 (4): 478-85.


Structural and functional role of the extracellular s5-p linker in the HERG potassium channel., Liu J., J Gen Physiol. November 1, 2002; 120 (5): 723-37.                  


Glutamate 172, essential for modulation of L247T alpha7 ACh receptors by Ca2+, lines the extracellular vestibule., Eddins D., Am J Physiol Cell Physiol. November 1, 2002; 283 (5): C1454-60.


Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?, Hilber K., J Biol Chem. October 4, 2002; 277 (40): 37105-15.


A tryptophan residue (W736) in the amino-terminus of the P-segment of domain II is involved in pore formation in Na(v)1.4 voltage-gated sodium channels., Carbonneau E., Pflugers Arch. October 1, 2002; 445 (1): 18-24.


Role of outer ring carboxylates of the rat skeletal muscle sodium channel pore in proton block., Khan A., J Physiol. August 15, 2002; 543 (Pt 1): 71-84.


Energetic localization of saxitoxin in its channel binding site., Choudhary G., Biophys J. August 1, 2002; 83 (2): 912-9.


Spermine block of the strong inward rectifier potassium channel Kir2.1: dual roles of surface charge screening and pore block., Xie LH., J Gen Physiol. July 1, 2002; 120 (1): 53-66.                  


Cocaine binds to a common site on open and inactivated human heart (Na(v)1.5) sodium channels., O'Leary ME., J Physiol. June 15, 2002; 541 (Pt 3): 701-16.


Role of anion-cation interactions on the pre-steady-state currents of the rat Na(+)-Cl(-)-dependent GABA cotransporter rGAT1., Bossi E., J Physiol. June 1, 2002; 541 (Pt 2): 343-50.


Effects of clomipramine on neuronal nicotinic acetylcholine receptors., López-Valdés HE., Eur J Pharmacol. May 24, 2002; 444 (1-2): 13-9.


Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore., Kashiwagi K., Mol Pharmacol. March 1, 2002; 61 (3): 533-45.

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