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Summary Anatomy Item Literature (2360) Expression Attributions Wiki

Papers associated with heart (and kcnh2)

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Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;               

The hERG channel activator, RPR260243, enhances protective IKr current early in the refractory period reducing arrhythmogenicity in zebrafish hearts., Shi YP., Am J Physiol Heart Circ Physiol. August 1, 2020; 319 (2): H251-H261.

Polyunsaturated fatty acid analogues differentially affect cardiac NaV, CaV, and KV channels through unique mechanisms., Bohannon BM., Elife. March 24, 2020; 9                                                               

Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds., Hull CM., Am J Physiol Regul Integr Comp Physiol. December 1, 2019; 317 (6): R921-R931.

Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels., Chen IS., Br J Pharmacol. September 1, 2019; 176 (17): 3161-3179.

The acute effects of hydrocortisone on cardiac electrocardiography, action potentials, intracellular calcium, and contraction: The role of protein kinase C., Park MH., Mol Cell Endocrinol. August 20, 2019; 494 110488.

Importance of the Choice of a Recombinant System to Produce Large Amounts of Functional Membrane Protein hERG., Vasseur L., Int J Mol Sci. June 28, 2019; 20 (13):           

Facilitation of IKr current by some hERG channel blockers suppresses early afterdepolarizations., Furutani K., J Gen Physiol. February 4, 2019; 151 (2): 214-230.                      

Dehydroevodiamine and hortiamine, alkaloids from the traditional Chinese herbal drug Evodia rutaecarpa, are IKr blockers with proarrhythmic effects in vitro and in vivo., Baburin I., Pharmacol Res. May 1, 2018; 131 150-163.

Inhibition of inwardly rectifying Kir2.x channels by the novel anti-cancer agent gambogic acid depends on both pore block and PIP2 interference., Scherer D., Naunyn Schmiedebergs Arch Pharmacol. July 1, 2017; 390 (7): 701-710.

Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4., Abbott GW., Sci Rep. December 6, 2016; 6 38412.              

Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium., Pedersen PJ., PLoS One. September 4, 2015; 10 (9): e0138320.                  

Eag Domains Regulate LQT Mutant hERG Channels in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes., Liu QN., PLoS One. April 22, 2015; 10 (4): e0123951.                

Concatenated hERG1 tetramers reveal stoichiometry of altered channel gating by RPR-260243., Wu W., Mol Pharmacol. January 1, 2015; 87 (3): 401-9.

Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels., Ng CA., J Biol Chem. September 12, 2014; 289 (37): 25822-32.

Concerted all-or-none subunit interactions mediate slow deactivation of human ether-à-go-go-related gene K+ channels., Thomson SJ., J Biol Chem. August 22, 2014; 289 (34): 23428-36.

The variant hERG/R148W associated with LQTS is a mutation that reduces current density on co-expression with the WT., Mechakra A., Gene. February 25, 2014; 536 (2): 348-56.            

Up-regulation of Kir2.1 (KCNJ2) by the serum & glucocorticoid inducible SGK3., Munoz C., Cell Physiol Biochem. January 1, 2014; 33 (2): 491-500.

Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel., Park MH., J Pharmacol Sci. September 20, 2013; 123 (1): 67-77.

Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels., Perry MD., J Gen Physiol. September 1, 2013; 142 (3): 275-88.                    

Mechanisms of zolpidem-induced long QT syndrome: acute inhibition of recombinant hERG K(+) channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells., Jehle J., Br J Pharmacol. March 1, 2013; 168 (5): 1215-29.

Blocking of the human ether-à-go-go-related gene channel by imatinib mesylate., Dong Q., Biol Pharm Bull. January 1, 2013; 36 (2): 268-75.

Kcnh1 voltage-gated potassium channels are essential for early zebrafish development., Stengel R., J Biol Chem. October 12, 2012; 287 (42): 35565-35575.            

Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway., Ferrer T., J Biol Chem. November 11, 2011; 286 (45): 39091-9.

Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells., Crottès D., J Biol Chem. August 12, 2011; 286 (32): 27947-58.

hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine., Staudacher I., Naunyn Schmiedebergs Arch Pharmacol. February 1, 2011; 383 (2): 119-39.

Differential effects of Kv11.1 activators on Kv11.1a, Kv11.1b and Kv11.1a/Kv11.1b channels., Larsen AP., Br J Pharmacol. October 1, 2010; 161 (3): 614-28.

Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride., Jo SH., Korean J Physiol Pharmacol. October 1, 2010; 14 (5): 305-10.

Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine., Obers S., Naunyn Schmiedebergs Arch Pharmacol. May 1, 2010; 381 (5): 385-400.

The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism., Gessner G., Eur J Pharmacol. April 25, 2010; 632 (1-3): 52-9.

Differential expression of hERG1 channel isoforms reproduces properties of native I(Kr) and modulates cardiac action potential characteristics., Larsen AP., PLoS One. February 2, 2010; 5 (2): e9021.            

Modulation of human ether a gogo related channels by CASQ2 contributes to etiology of catecholaminergic polymorphic ventricular tachycardia (CPVT)., Eckey K., Cell Physiol Biochem. January 1, 2010; 26 (4-5): 503-12.

Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents., Scherer D., Br J Pharmacol. January 1, 2009; 156 (2): 226-36.

Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation., Barrows B., Channels (Austin). January 1, 2009; 3 (4): 239-48.

Papaverine, a vasodilator, blocks the pore of the HERG channel at submicromolar concentration., Kim YJ., J Cardiovasc Pharmacol. December 1, 2008; 52 (6): 485-93.

Characterization of hERG1a and hERG1b potassium channels-a possible role for hERG1b in the I (Kr) current., Larsen AP., Pflugers Arch. September 1, 2008; 456 (6): 1137-48.

Topological mapping of the asymmetric drug binding to the human ether-à-go-go-related gene product (HERG) potassium channel by use of tandem dimers., Myokai T., Mol Pharmacol. June 1, 2008; 73 (6): 1643-51.

Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide., Lin C., Cardiology. January 1, 2008; 110 (3): 209-16.

Cooperative interactions between R531 and acidic residues in the voltage sensing module of hERG1 channels., Piper DR., Cell Physiol Biochem. January 1, 2008; 21 (1-3): 37-46.

Zebrafish model for human long QT syndrome., Arnaout R., Proc Natl Acad Sci U S A. July 3, 2007; 104 (27): 11316-21.

Molecular interaction of droperidol with human ether-a-go-go-related gene channels: prolongation of action potential duration without inducing early afterdepolarization., Schwoerer AP., Anesthesiology. May 1, 2007; 106 (5): 967-76.

Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure., Watanabe E., Circ J. April 1, 2007; 71 (4): 471-8.

The effect of high extracellular potassium on IKr inhibition by anti-arrhythmic agents., Lin C., Cardiology. January 1, 2007; 108 (1): 18-27.

Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N''-(3''-trifluoromethylphenyl)urea]., Hansen RS., Mol Pharmacol. October 1, 2006; 70 (4): 1319-29.

Blockade of HERG human K+ channel and IKr of guinea pig cardiomyocytes by prochlorperazine., Kim MD., Eur J Pharmacol. August 21, 2006; 544 (1-3): 82-90.

Blockade of HERG human K+ channels and IKr of guinea-pig cardiomyocytes by the antipsychotic drug clozapine., Lee SY., Br J Pharmacol. June 1, 2006; 148 (4): 499-509.

Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels., Diness TG., Biochem Biophys Res Commun. May 19, 2006; 343 (4): 1224-33.

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)., Hansen RS., Mol Pharmacol. January 1, 2006; 69 (1): 266-77.

Expression and functional characterization of the human ether-à-go-go-related gene (HERG) K+ channel cardiac splice variant in Xenopus laevis oocytes., Aydar E., J Membr Biol. January 1, 2006; 211 (2): 115-26.

In vivo targeting of ERG potassium channels in mice and dogs by a positron-emitting analogue of fluoroclofilium., Kim SW., Exp Mol Med. August 31, 2005; 37 (4): 269-75.

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