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Summary Anatomy Item Literature (2432) Expression Attributions Wiki
XB-ANAT-63

Papers associated with heart (and hcn4)

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Two HCN4 Channels Play Functional Roles in the Zebrafish Heart., Liu J., Front Physiol. January 1, 2022; 13 901571.


Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;               


Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking., Erlenhardt N., Pflugers Arch. December 1, 2020; 472 (12): 1733-1742.      


The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function., Silbernagel N., FASEB J. November 1, 2018; 32 (11): 6159-6173.            


Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family., Alvarez-Baron CP., J Gen Physiol. August 6, 2018; 150 (8): 1203-1213.            


HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner., Pai VP., Biol Open. October 15, 2017; 6 (10): 1445-1457.                              


Id genes are essential for early heart formation., Cunningham TJ., Genes Dev. July 1, 2017; 31 (13): 1325-1338.                


Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis., Pitcairn E., Commun Integr Biol. May 10, 2017; 10 (3): e1309488.                            


Direct nkx2-5 transcriptional repression of isl1 controls cardiomyocyte subtype identity., Dorn T., Stem Cells. April 1, 2015; 33 (4): 1113-29.              


Berberine attenuates spontaneous action potentials in sinoatrial node cells and the currents of human HCN4 channels expressed in Xenopus laevis oocytes., Chen H., Mol Med Rep. September 1, 2014; 10 (3): 1576-82.


Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation., Mesirca P., Nat Commun. August 21, 2014; 5 4664.                


The cAMP-binding Popdc proteins have a redundant function in the heart., Brand T., Biochem Soc Trans. April 1, 2014; 42 (2): 295-301.      


Local and global interpretations of a disease-causing mutation near the ligand entry path in hyperpolarization-activated cAMP-gated channel., Xu X., Structure. December 5, 2012; 20 (12): 2116-23.


Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents., Chen Y., Alcohol Clin Exp Res. December 1, 2012; 36 (12): 2036-46.


Blocking effects of acehytisine on pacemaker currents (I(f)) in sinoatrial node cells and human HCN4 channels expressed in Xenopus laevis oocytes., Fan X., J Ethnopharmacol. January 6, 2012; 139 (1): 42-51.


Local anesthetic inhibits hyperpolarization-activated cationic currents., Meng QT., Mol Pharmacol. May 1, 2011; 79 (5): 866-73.


A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews., Laish-Farkash A., J Cardiovasc Electrophysiol. December 1, 2010; 21 (12): 1365-72.


Structural basis for the cAMP-dependent gating in the human HCN4 channel., Xu X., J Biol Chem. November 19, 2010; 285 (47): 37082-91.


Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation., Zolles G., Neuron. June 25, 2009; 62 (6): 814-25.


Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes., Zhang Q., Biochim Biophys Acta. May 1, 2009; 1788 (5): 1138-47.


Shox2 is essential for the differentiation of cardiac pacemaker cells by repressing Nkx2-5., Espinoza-Lewis RA., Dev Biol. March 15, 2009; 327 (2): 376-85.      


Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels., Elinder F., J Physiol. September 1, 2006; 575 (Pt 2): 417-31.


Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol., Cacheaux LP., J Pharmacol Exp Ther. November 1, 2005; 315 (2): 517-25.


Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels., Yu HG., Pflugers Arch. January 1, 2004; 447 (4): 392-400.


KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents., Decher N., Pflugers Arch. September 1, 2003; 446 (6): 633-40.


Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide., Chen S., J Gen Physiol. May 1, 2001; 117 (5): 491-504.                  

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