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Summary Anatomy Item Literature (2360) Expression Attributions Wiki

Papers associated with heart (and kcnq1)

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Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277., Willegems K., Nat Commun. June 29, 2022; 13 (1): 3760.

Virus-Host Interactions of Enteroviruses and Parvovirus B19 in Myocarditis., Ho HT., Cell Physiol Biochem. November 18, 2021; 55 (6): 679-703.        

Molecular Mechanism of Autosomal Recessive Long QT-Syndrome 1 without Deafness., Oertli A., Int J Mol Sci. January 23, 2021; 22 (3):             

A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation., Liu Y., Commun Biol. July 16, 2020; 3 (1): 385.

4,4'-Diisothiocyanato-2,2'-Stilbenedisulfonic Acid (DIDS) Modulates the Activity of KCNQ1/KCNE1 Channels by an Interaction with the Central Pore Region., Bollmann E., Cell Physiol Biochem. April 8, 2020; 54 (2): 321-332.

ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling., Hou P., Elife. July 22, 2019; 8                     

Probing the Dynamics and Structural Topology of the Reconstituted Human KCNQ1 Voltage Sensor Domain (Q1-VSD) in Lipid Bilayers Using Electron Paramagnetic Resonance Spectroscopy., Dixit G., Biochemistry. February 19, 2019; 58 (7): 965-973.

KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions., Barro-Soria R., Proc Natl Acad Sci U S A. August 29, 2017; 114 (35): E7367-E7376.

Molecular cloning and functional expression of the K + channel K V 7.1 and the regulatory subunit KCNE1 from equine myocardium., Pedersen PJ., Res Vet Sci. August 1, 2017; 113 79-86.

The residue I257 at S4-S5 linker in KCNQ1 determines KCNQ1/KCNE1 channel sensitivity to 1-alkanols., Xie C., Acta Pharmacol Sin. January 1, 2016; 37 (1): 124-33.          

Insulin suppresses IKs (KCNQ1/KCNE1) currents, which require β-subunit KCNE1., Wu M., Pflugers Arch. May 1, 2014; 466 (5): 937-46.

Domain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel., Zaydman MA., Elife. March 12, 2014; 3 e03606.                        

Intracellular ATP binding is required to activate the slowly activating K+ channel I(Ks)., Li Y., Proc Natl Acad Sci U S A. November 19, 2013; 110 (47): 18922-7.

Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene., Geng FS., Development. November 1, 2013; 140 (21): 4362-74.              

Differential effects of ginsenoside metabolites on slowly activating delayed rectifier K(+) and KCNQ1 K(+) channel currents., Choi SH., J Ginseng Res. July 1, 2013; 37 (3): 324-31.          

Rab GTPases are required for early orientation of the left-right axis in Xenopus., Vandenberg LN., Mech Dev. January 1, 2013; 130 (4-5): 254-71.                      

Regulation of KCNQ1/KCNE1 by β-catenin., Wilmes J., Mol Membr Biol. January 1, 2012; 29 (3-4): 87-94.

Reconstitution of KCNE1 into lipid bilayers: comparing the structural, dynamic, and activity differences in micelle and vesicle environments., Coey AT., Biochemistry. December 20, 2011; 50 (50): 10851-9.

Identification and functional characterization of KCNQ1 mutations around the exon 7-intron 7 junction affecting the splicing process., Tsuji-Wakisaka K., Biochim Biophys Acta. November 1, 2011; 1812 (11): 1452-9.

KCNQ1 subdomains involved in KCNE modulation revealed by an invertebrate KCNQ1 orthologue., Nakajo K., J Gen Physiol. November 1, 2011; 138 (5): 521-35.                        

Extracellular potassium inhibits Kv7.1 potassium channels by stabilizing an inactivated state., Larsen AP., Biophys J. August 17, 2011; 101 (4): 818-27.

Inhibition of the heterotetrameric K+ channel KCNQ1/KCNE1 by the AMP-activated protein kinase., Alesutan I., Mol Membr Biol. February 1, 2011; 28 (2): 79-89.

Stoichiometry of the KCNQ1 - KCNE1 ion channel complex., Nakajo K., Proc Natl Acad Sci U S A. November 2, 2010; 107 (44): 18862-7.

PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors., Matavel A., J Mol Cell Cardiol. May 1, 2009; 46 (5): 704-12.

Mechanisms by which atrial fibrillation-associated mutations in the S1 domain of KCNQ1 slow deactivation of IKs channels., Restier L., J Physiol. September 1, 2008; 586 (17): 4179-91.

KCNQ1 and KCNE1 in the IKs channel complex make state-dependent contacts in their extracellular domains., Xu X., J Gen Physiol. June 1, 2008; 131 (6): 589-603.                    

Counting membrane-embedded KCNE beta-subunits in functioning K+ channel complexes., Morin TJ., Proc Natl Acad Sci U S A. February 5, 2008; 105 (5): 1478-82.

KCNQ1 mutation Q147R is associated with atrial fibrillation and prolonged QT interval., Lundby A., Heart Rhythm. December 1, 2007; 4 (12): 1532-41.

Serial perturbation of MinK in IKs implies an alpha-helical transmembrane span traversing the channel corpus., Chen H., Biophys J. October 1, 2007; 93 (7): 2332-40.

KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channel., Nakajo K., J Gen Physiol. September 1, 2007; 130 (3): 269-81.            

A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes., Morin TJ., ACS Chem Biol. July 20, 2007; 2 (7): 469-73.

Upregulation of KCNE1 induces QT interval prolongation in patients with chronic heart failure., Watanabe E., Circ J. April 1, 2007; 71 (4): 471-8.

Mechanistic basis for the pathogenesis of long QT syndrome associated with a common splicing mutation in KCNQ1 gene., Tsuji K., J Mol Cell Cardiol. March 1, 2007; 42 (3): 662-9.

The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes., Panaghie G., J Gen Physiol. February 1, 2007; 129 (2): 121-33.                      

KCNE2 is colocalized with KCNQ1 and KCNE1 in cardiac myocytes and may function as a negative modulator of I(Ks) current amplitude in the heart., Wu DM., Heart Rhythm. December 1, 2006; 3 (12): 1469-80.

Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome., Zehelein J., J Biol Chem. November 17, 2006; 281 (46): 35397-403.

Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel., Bett GC., J Physiol. November 1, 2006; 576 (Pt 3): 755-67.

Frequency-dependent modulation of KCNQ1 and HERG1 potassium channels., Diness TG., Biochem Biophys Res Commun. May 19, 2006; 343 (4): 1224-33.

Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels., Seebohm G., J Physiol. March 1, 2005; 563 (Pt 2): 359-68.

Analysis of QT Interval Prolongation With Heart Failure by Simulation of Repolarization Process., Yamaguchi T., Conf Proc IEEE Eng Med Biol Soc. January 1, 2005; 2005 7309-12.

Identification and characterisation of a novel KCNQ1 mutation in a family with Romano-Ward syndrome., Zehelein J., Biochim Biophys Acta. November 5, 2004; 1690 (3): 185-92.

Basolateral localisation of KCNQ1 potassium channels in MDCK cells: molecular identification of an N-terminal targeting motif., Jespersen T., J Cell Sci. September 1, 2004; 117 (Pt 19): 4517-26.

Association of the serum and glucocorticoid regulated kinase (sgk1) gene with QT interval., Busjahn A., Cell Physiol Biochem. January 1, 2004; 14 (3): 135-42.

KCNQ1 channels sense small changes in cell volume., Grunnet M., J Physiol. June 1, 2003; 549 (Pt 2): 419-27.

Novel gene hKCNE4 slows the activation of the KCNQ1 channel., Teng S., Biochem Biophys Res Commun. April 11, 2003; 303 (3): 808-13.

Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms., Embark HM., Pflugers Arch. February 1, 2003; 445 (5): 601-6.

KCNE5 induces time- and voltage-dependent modulation of the KCNQ1 current., Angelo K., Biophys J. October 1, 2002; 83 (4): 1997-2006.

A truncated splice variant of KCNQ1 cloned from rat heart., Yamada Y., Biochem Biophys Res Commun. June 7, 2002; 294 (2): 199-204.

Dependence of I(Ks) biophysical properties on the expression system., Seebohm G., Pflugers Arch. September 1, 2001; 442 (6): 891-5.

Identification of specific pore residues mediating KCNQ1 inactivation. A novel mechanism for long QT syndrome., Seebohm G., J Biol Chem. April 27, 2001; 276 (17): 13600-5.

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