Papers associated with heart (and hcn2)

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	HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling., Pai VP., Wound Repair Regen. November 1, 2022; 30 (6): 681-706.
	Bioelectric signaling: Reprogrammable circuits underlying embryogenesis, regeneration, and cancer., Levin M., Cell. April 15, 2021;
	The HCN domain is required for HCN channel cell-surface expression and couples voltage- and cAMP-dependent gating mechanisms., Wang ZJ., J Biol Chem. June 12, 2020; 295 (24): 8164-8173.
	HCN2 Channel-Induced Rescue of Brain Teratogenesis via Local and Long-Range Bioelectric Repair., Pai VP., Front Cell Neurosci. January 1, 2020; 14 136.
	cAMP binds to closed, inactivated, and open sea urchin HCN channels in a state-dependent manner., Idikuda V., J Gen Physiol. February 4, 2019; 151 (2): 200-213.
	The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function., Silbernagel N., FASEB J. November 1, 2018; 32 (11): 6159-6173.
	All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner., Sunkara MR., J Gen Physiol. September 3, 2018; 150 (9): 1261-1271.
	Minimal molecular determinants of isoform-specific differences in efficacy in the HCN channel family., Alvarez-Baron CP., J Gen Physiol. August 6, 2018; 150 (8): 1203-1213.
	Ligand binding and activation properties of the purified bacterial cyclic nucleotide-gated channel SthK., Schmidpeter PAM., J Gen Physiol. June 4, 2018; 150 (6): 821-834.
	Activation gating in HCN2 channels., Hummert S., PLoS Comput Biol. March 22, 2018; 14 (3): e1006045.
	HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a nodal and lefty asymmetric gene expression-independent manner., Pai VP., Biol Open. October 15, 2017; 6 (10): 1445-1457.
	A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction., Stallmeyer B., Circ Res. May 12, 2017; 120 (10): e33-e44.
	Coordinating heart morphogenesis: A novel role for hyperpolarization-activated cyclic nucleotide-gated (HCN) channels during cardiogenesis in Xenopus laevis., Pitcairn E., Commun Integr Biol. May 10, 2017; 10 (3): e1309488.
	Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides., Thon S., Biophys J. December 1, 2015; 109 (11): 2268-76.
	HCN2 channels: a permanent open state and conductance changes., Pittoors F., J Membr Biol. February 1, 2015; 248 (1): 67-81.
	Flavonoid regulation of HCN2 channels., Carlson AE., J Biol Chem. November 15, 2013; 288 (46): 33136-45.
	Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents., Chen Y., Alcohol Clin Exp Res. December 1, 2012; 36 (12): 2036-46.
	A leucine zipper motif essential for gating of hyperpolarization-activated channels., Wemhöner K., J Biol Chem. November 23, 2012; 287 (48): 40150-60.
	Local anesthetic inhibits hyperpolarization-activated cationic currents., Meng QT., Mol Pharmacol. May 1, 2011; 79 (5): 866-73.
	Structural basis for the cAMP-dependent gating in the human HCN4 channel., Xu X., J Biol Chem. November 19, 2010; 285 (47): 37082-91.
	Tanshinone IIA selectively enhances hyperpolarization-activated cyclic nucleotide-modulated (HCN) channel instantaneous current., Liang Q., J Pharmacol Sci. July 1, 2009; 110 (3): 381-8.
	Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation., Zolles G., Neuron. June 25, 2009; 62 (6): 814-25.
	Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes., Zhang Q., Biochim Biophys Acta. May 1, 2009; 1788 (5): 1138-47.
	Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels., Cheng L., J Pharmacol Exp Ther. September 1, 2007; 322 (3): 931-9.
	Wild-type and mutant HCN channels in a tandem biological-electronic cardiac pacemaker., Bucchi A., Circulation. September 5, 2006; 114 (10): 992-9.
	Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels., Elinder F., J Physiol. September 1, 2006; 575 (Pt 2): 417-31.
	Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol., Cacheaux LP., J Pharmacol Exp Ther. November 1, 2005; 315 (2): 517-25.
	Tyrosine kinase inhibition differentially regulates heterologously expressed HCN channels., Yu HG., Pflugers Arch. January 1, 2004; 447 (4): 392-400.
	KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents., Decher N., Pflugers Arch. September 1, 2003; 446 (6): 633-40.
	Regulation of hyperpolarization-activated HCN channel gating and cAMP modulation due to interactions of COOH terminus and core transmembrane regions., Wang J., J Gen Physiol. September 1, 2001; 118 (3): 237-50.
	Properties of hyperpolarization-activated pacemaker current defined by coassembly of HCN1 and HCN2 subunits and basal modulation by cyclic nucleotide., Chen S., J Gen Physiol. May 1, 2001; 117 (5): 491-504.
	Inhibition of IKs channels by HMR 1556., Gögelein H., Naunyn Schmiedebergs Arch Pharmacol. December 1, 2000; 362 (6): 480-8.
	Functional roles of charged residues in the putative voltage sensor of the HCN2 pacemaker channel., Chen J., J Biol Chem. November 17, 2000; 275 (46): 36465-71.

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