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R-Spondin 2 governs Xenopus left- right body axis formation by establishing an FGF signaling gradient. , Lee H , Lee H ., Nat Commun. February 2, 2024; 15 (1): 1003.
Uncoupling the BMP receptor antagonist function from the WNT agonist function of R-spondin 2 using the inhibitory peptide dendrimer RWd. , Lee H , Lee H ., J Biol Chem. February 1, 2022; 298 (2): 101586.
R-spondins are BMP receptor antagonists in Xenopus early embryonic development. , Lee H , Lee H ., Nat Commun. November 4, 2020; 11 (1): 5570.
The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. , Chang LS., Elife. January 14, 2020; 9
Angiopoietin-like 4 Is a Wnt Signaling Antagonist that Promotes LRP6 Turnover. , Kirsch N., Dev Cell. October 9, 2017; 43 (1): 71-82.e6.
Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. , Ohkawara B., Dev Cell. March 15, 2011; 20 (3): 303-14.
Wnt/beta-catenin signaling is involved in the induction and maintenance of primitive hematopoiesis in the vertebrate embryo. , Tran HT., Proc Natl Acad Sci U S A. September 14, 2010; 107 (37): 16160-5.
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development. , Kazanskaya O., Development. November 1, 2008; 135 (22): 3655-64.
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. , Kazanskaya O., Dev Cell. October 1, 2004; 7 (4): 525-34.