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Advancements in the use of xenopus oocytes for modelling neurological disease for novel drug discovery. , O'Connor EC., Expert Opin Drug Discov. February 1, 2024; 19 (2): 173-187.
Sea anemone Bartholomea annulata venom inhibits voltage-gated Na+ channels and activates GABAA receptors from mammals. , Colom-Casasnovas A., Sci Rep. March 30, 2022; 12 (1): 5352.
A critical residue in the α1M2-M3 linker regulating mammalian GABAA receptor pore gating by diazepam. , Nors JW., Elife. February 16, 2021; 10
GABAA Receptor Subunit Composition Drives Its Sensitivity to the Insecticide Fipronil. , Soualah Z., Front Neurosci. January 1, 2021; 15 768466.
In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders. , Grupe M., Eur J Pharmacol. November 15, 2020; 887 173440.
Direct neurotransmitter activation of voltage-gated potassium channels. , Manville RW., Nat Commun. May 10, 2018; 9 (1): 1847.
Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels. , Fourati Z., Cell Rep. April 24, 2018; 23 (4): 993-1004.
Towards functional selectivity for α6β3γ2 GABAA receptors: a series of novel pyrazoloquinolinones. , Treven M., Br J Pharmacol. February 1, 2018; 175 (3): 419-428.
Diversity of Nicotinic Acetylcholine Receptor Positive Allosteric Modulators Revealed by Mutagenesis and a Revised Structural Model. , Newcombe J., Mol Pharmacol. February 1, 2018; 93 (2): 128-140.
Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant. , Shelukhina IV., Toxins (Basel). January 7, 2018; 10 (1):
The novel isoxazoline ectoparasiticide lotilaner (Credelio™): a non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). , Rufener L., Parasit Vectors. November 1, 2017; 10 (1): 530.
Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. , Savechenkov PY., Eur J Med Chem. August 18, 2017; 136 334-347.
Molecular tools for GABAA receptors: High affinity ligands for β1-containing subtypes. , Simeone X., Sci Rep. July 18, 2017; 7 (1): 5674.
Low Expression in Xenopus Oocytes and Unusual Functional Properties of α1β2γ2 GABAA Receptors with Non-Conventional Subunit Arrangement. , Baur R., PLoS One. January 3, 2017; 12 (1): e0170572.
Cannabis in epilepsy: From clinical practice to basic research focusing on the possible role of cannabidivarin. , Morano A., Epilepsia Open. September 19, 2016; 1 (3-4): 145-151.
Zolpidem is a potent stoichiometry-selective modulator of α1β3 GABAA receptors: evidence of a novel benzodiazepine site in the α1-α1 interface. , Che Has AT., Sci Rep. June 27, 2016; 6 28674.
Correction for Inhibition Leads to an Allosteric Co-Agonist Model for Pentobarbital Modulation and Activation of α1β3γ2L GABAA Receptors. , Ziemba AM., PLoS One. April 21, 2016; 11 (4): e0154031.
Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels. , Bertozzi C., PLoS Biol. March 4, 2016; 14 (3): e1002393.
Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects. , Desai R., J Physiol. November 15, 2015; 593 (22): 4943-61.
The Direct Actions of GABA, 2'-Methoxy-6-Methylflavone and General Anaesthetics at β3γ2L GABAA Receptors: Evidence for Receptors with Different Subunit Stoichiometries. , Chua HC., PLoS One. October 20, 2015; 10 (10): e0141359.
Interactions of L-3,5,3'-Triiodothyronine [corrected], Allopregnanolone, and Ivermectin with the GABAA Receptor: Evidence for Overlapping Intersubunit Binding Modes. , Westergard T., PLoS One. September 4, 2015; 10 (9): e0139072.
The desensitization gate of inhibitory Cys-loop receptors. , Gielen M., Nat Commun. April 20, 2015; 6 6829.
Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. , Brosnan RJ., BMC Pharmacol Toxicol. November 19, 2014; 15 62.
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). , Spurny R., J Biol Chem. March 22, 2013; 288 (12): 8355-8364.
Partial agonism of taurine at gamma-containing native and recombinant GABAA receptors. , Kletke O., PLoS One. January 1, 2013; 8 (4): e61733.
A single amino acid determines the toxicity of Ginkgo biloba extracts. , Thompson AJ., FASEB J. May 1, 2012; 26 (5): 1884-91.
The biochemical anatomy of cortical inhibitory synapses. , Heller EA., PLoS One. January 1, 2012; 7 (6): e39572.
Cloning and characterization of GABAA α subunits and GABAB subunits in Xenopus laevis during development. , Kaeser GE., Dev Dyn. April 1, 2011; 240 (4): 862-73.
GABAergic circuits control stimulus-instructed receptive field development in the optic tectum. , Richards BA., Nat Neurosci. September 1, 2010; 13 (9): 1098-106.
m-Azipropofol (AziPm) a photoactive analogue of the intravenous general anesthetic propofol. , Hall MA., J Med Chem. August 12, 2010; 53 (15): 5667-75.
About a snail, a toad, and rodents: animal models for adaptation research. , Roubos EW ., Front Endocrinol (Lausanne). January 1, 2010; 1 4.
The location of a closed channel gate in the GABAA receptor channel. , Bali M., J Gen Physiol. February 1, 2007; 129 (2): 145-59.
A single M1 residue in the beta2 subunit alters channel gating of GABAA receptor in anesthetic modulation and direct activation. , Chang CS ., J Biol Chem. October 31, 2003; 278 (44): 42821-8.
Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug. , Sinkkonen ST., Mol Pharmacol. September 1, 2003; 64 (3): 753-63.
Neuronal representation of odourants in the olfactory bulb of Xenopus laevis tadpoles. , Czesnik D., Eur J Neurosci. January 1, 2003; 17 (1): 113-8.
Anion permeation in Ca(2+)-activated Cl(-) channels. , Qu Z., J Gen Physiol. December 1, 2000; 116 (6): 825-44.
Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors. , Labarca C., Nature. August 10, 1995; 376 (6540): 514-6.
Differences in affinity and efficacy of benzodiazepine receptor ligands at recombinant gamma-aminobutyric acidA receptor subtypes. , Wafford KA., Mol Pharmacol. February 1, 1993; 43 (2): 240-4.