Kaltenbrun E , Tandon P , Amin NM , Waldron L , Showell C , Conlon FL .

R01 DE018825 NIDCR NIH HHS, R01 DE018825-01A1 NIDCR NIH HHS, R01 DE018825-04 NIDCR NIH HHS, R01 HL089641 NHLBI NIH HHS , R01 HL089641-01A1 NHLBI NIH HHS

Abu-Daya, Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6. 2009, Pubmed, Xenbase

Abu-Daya, Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6. 2009, Pubmed , Xenbase
Adams, Defects in vestibular sensory epithelia and innervation in mice with loss of Chd7 function: implications for human CHARGE syndrome. 2007, Pubmed
Afouda, GATA transcription factors integrate Wnt signalling during heart development. 2008, Pubmed , Xenbase
Ai, Pitx2 regulates cardiac left-right asymmetry by patterning second cardiac lineage-derived myocardium. 2006, Pubmed
Akkus, Congenital heart defects in two siblings in an Axenfeld-Rieger syndrome family. 2010, Pubmed
Allen, Transgenic Xenopus laevis embryos can be generated using phiC31 integrase. 2005, Pubmed , Xenbase
Allen, Bacteriophage phiC31 integrase mediated transgenesis in Xenopus laevis for protein expression at endogenous levels. 2009, Pubmed , Xenbase
Amaya, A method for generating transgenic frog embryos. 1999, Pubmed , Xenbase
Amendt, Rieger syndrome: a clinical, molecular, and biochemical analysis. 2000, Pubmed
Andres, Persistence, methylation and expression of vitellogenin gene derivatives after injection into fertilized eggs of Xenopus laevis. 1984, Pubmed , Xenbase
Antevil, Idiopathic mitral valve disease in a patient presenting with Axenfeld-Rieger syndrome. 2009, Pubmed
Aramaki, Embryonic expression profile of chicken CHD7, the ortholog of the causative gene for CHARGE syndrome. 2007, Pubmed
Aramaki, Phenotypic spectrum of CHARGE syndrome with CHD7 mutations. 2006, Pubmed
Ariizumi, Amphibian in vitro heart induction: a simple and reliable model for the study of vertebrate cardiac development. 2003, Pubmed , Xenbase
Ataliotis, XTbx1 is a transcriptional activator involved in head and pharyngeal arch development in Xenopus laevis. 2005, Pubmed , Xenbase
Attenhofer Jost, Ebstein's anomaly - review of a multifaceted congenital cardiac condition. 2005, Pubmed
Ayşenur Paç, Axenfeld-Rieger syndrome and pseudotruncus arteriosus. 2008, Pubmed
Bajpai, CHD7 cooperates with PBAF to control multipotent neural crest formation. 2010, Pubmed , Xenbase
Baldini, DiGeorge syndrome: an update. 2004, Pubmed
Bartlett, Transient early embryonic expression of Nkx2-5 mutations linked to congenital heart defects in human causes heart defects in Xenopus laevis. 2007, Pubmed , Xenbase
Bartlett, Lessons from the lily pad: Using Xenopus to understand heart disease. 2008, Pubmed , Xenbase
Bartlett, Characterization of embryonic cardiac pacemaker and atrioventricular conduction physiology in Xenopus laevis using noninvasive imaging. 2004, Pubmed , Xenbase
Baruch, Axenfeld-Rieger anomaly, hypertelorism, clinodactyly, and cardiac anomalies in sibs with an unbalanced translocation der(6)t(6;8). 2001, Pubmed
Basson, Different TBX5 interactions in heart and limb defined by Holt-Oram syndrome mutations. 1999, Pubmed
Basson, The clinical and genetic spectrum of the Holt-Oram syndrome (heart-hand syndrome). 1994, Pubmed
Basson, Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome. 1997, Pubmed
Batsukh, CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome. 2010, Pubmed
Bekir, Atrial septal defect with interatrial aneurysm and Axenfeld-Rieger syndrome. 2000, Pubmed
Belmont, Molecular genetics of heterotaxy syndromes. 2004, Pubmed
Bendig, Differential expression of the Xenopus laevis tadpole and adult beta-globin genes when injected into fertilized Xenopus laevis eggs. 1984, Pubmed , Xenbase
Benson, Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. 1999, Pubmed , Xenbase
Benson, New understandings in the genetics of congenital heart disease. 1996, Pubmed
Bentires-Alj, Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. 2004, Pubmed
Bill, A primer for morpholino use in zebrafish. 2009, Pubmed
Blum, Xenopus, an ideal model system to study vertebrate left-right asymmetry. 2009, Pubmed , Xenbase
Boorman, The evolution of left-right asymmetry in chordates. 2002, Pubmed
Bosman, Multiple mutations in mouse Chd7 provide models for CHARGE syndrome. 2005, Pubmed
Bowers, The genetics of left-right development and heterotaxia. 1996, Pubmed
Branford, Regulation of gut and heart left-right asymmetry by context-dependent interactions between xenopus lefty and BMP4 signaling. 2000, Pubmed , Xenbase
Brassington, Expressivity of Holt-Oram syndrome is not predicted by TBX5 genotype. 2003, Pubmed
Breckenridge, A role for BMP signalling in heart looping morphogenesis in Xenopus. 2001, Pubmed , Xenbase
Brown, Small heat shock protein Hsp27 is required for proper heart tube formation. 2007, Pubmed , Xenbase
Brown, Tbx5 and Tbx20 act synergistically to control vertebrate heart morphogenesis. 2005, Pubmed , Xenbase
Bruneau, A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. 2001, Pubmed
Cai, T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. 2005, Pubmed
Calcagni, Concordant familial segregation of atrial septal defect and Axenfeld-Rieger anomaly in father and son. 2006, Pubmed
Campione, The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping. 1999, Pubmed , Xenbase
Cha, The role of FoxC1 in early Xenopus development. 2007, Pubmed , Xenbase
Chalmers, A Xenopus tropicalis oligonucleotide microarray works across species using RNA from Xenopus laevis. 2005, Pubmed , Xenbase
Chapman, Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. 1996, Pubmed
Chen, ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus. 2004, Pubmed , Xenbase
Chen, Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis. 2000, Pubmed
Chesneau, Transgenesis procedures in Xenopus. 2008, Pubmed , Xenbase
Choo, Zebrafish transgenic Enhancer TRAP line database (ZETRAP). 2006, Pubmed
Christine, Vertebrate CASTOR is required for differentiation of cardiac precursor cells at the ventral midline. 2008, Pubmed , Xenbase
Clark, Transcription factors and congenital heart defects. 2006, Pubmed
Cross, The mutation spectrum in Holt-Oram syndrome. 2000, Pubmed
Cunningham, Familial Axenfeld-Rieger anomaly, atrial septal defect, and sensorineural hearing loss: a possible new genetic syndrome. 1998, Pubmed
Dagle, Oligonucleotide-based strategies to reduce gene expression. 2001, Pubmed , Xenbase
Dagle, Pitx2c attenuation results in cardiac defects and abnormalities of intestinal orientation in developing Xenopus laevis. 2003, Pubmed , Xenbase
Dale, Fate map for the 32-cell stage of Xenopus laevis. 1987, Pubmed , Xenbase
Davenport, The spectrum of clinical features in CHARGE syndrome. 1986, Pubmed
Davies, Delineation of two distinct 6p deletion syndromes. 1999, Pubmed
Delahaye, Familial CHARGE syndrome because of CHD7 mutation: clinical intra- and interfamilial variability. 2007, Pubmed
Di Felice, Tetralogy of fallot as a model to study cardiac progenitor cell migration and differentiation during heart development. 2009, Pubmed
Durocher, The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors. 1997, Pubmed , Xenbase
Eisen, Controlling morpholino experiments: don't stop making antisense. 2008, Pubmed , Xenbase
Epstein, Developing models of DiGeorge syndrome. 2001, Pubmed
Eralp, Epicardium-derived cells are important for correct development of the Purkinje fibers in the avian heart. 2006, Pubmed
Essner, Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms. 2000, Pubmed , Xenbase
Etkin, Transmission of integrated sea urchin histone genes by nuclear transplantation in Xenopus laevis. 1983, Pubmed , Xenbase
Etkin, Replication, integration and expression of exogenous DNA injected into fertilized eggs of Xenopus laevis. 1984, Pubmed , Xenbase
Etkin, Distribution, expression and germ line transmission of exogenous DNA sequences following microinjection into Xenopus laevis eggs. 1987, Pubmed , Xenbase
Evans, Myocardial lineage development. 2010, Pubmed
Feng, Receptor-binding, tyrosine phosphorylation and chromosome localization of the mouse SH2-containing phosphotyrosine phosphatase Syp. 1994, Pubmed
Feng, Shp-2 tyrosine phosphatase: signaling one cell or many. 1999, Pubmed
Foley, Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex. 2005, Pubmed , Xenbase
Gage, Dosage requirement of Pitx2 for development of multiple organs. 1999, Pubmed
Galli, Atrial myocardium derives from the posterior region of the second heart field, which acquires left-right identity as Pitx2c is expressed. 2008, Pubmed
Garavelli, Holt-Oram syndrome associated with anomalies of the feet. 2008, Pubmed
Garg, GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. 2003, Pubmed , Xenbase
Garriock, Developmental expression and comparative genomic analysis of Xenopus cardiac myosin heavy chain genes. 2005, Pubmed , Xenbase
Garriock, Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus. 2005, Pubmed , Xenbase
Garrity, The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. 2002, Pubmed
Geach, Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky ticker. 2010, Pubmed , Xenbase
Gebbia, X-linked situs abnormalities result from mutations in ZIC3. 1997, Pubmed
Gessert, Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis. 2009, Pubmed , Xenbase
Gittenberger-de Groot, Epicardial outgrowth inhibition leads to compensatory mesothelial outflow tract collar and abnormal cardiac septation and coronary formation. 2000, Pubmed
Gittenberger-de Groot, Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. 1998, Pubmed
Goetz, TBX5 is required for embryonic cardiac cell cycle progression. 2006, Pubmed , Xenbase
Gormley, Left and right contributions to the Xenopus heart: implications for asymmetric morphogenesis. 2003, Pubmed , Xenbase
Grosso, Familial Axenfeld-Rieger anomaly, cardiac malformations, and sensorineural hearing loss: a provisionally unique genetic syndrome? 2002, Pubmed
Grunz, Suramin changes the fate of Spemann's organizer and prevents neural induction in Xenopus laevis. 1992, Pubmed , Xenbase
Grépin, Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. 1997, Pubmed
Grépin, Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. 1995, Pubmed
HOLT, Familial heart disease with skeletal malformations. 1960, Pubmed
Hamlet, Tol2 transposon-mediated transgenesis in Xenopus tropicalis. 2006, Pubmed , Xenbase
Hammer, Characterization of TBX20 in human hearts and its regulation by TFAP2. 2008, Pubmed
Hanafusa, Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. 2004, Pubmed
Hang, Chromatin regulation by Brg1 underlies heart muscle development and disease. 2010, Pubmed
Harland, Translation of mRNA injected into Xenopus oocytes is specifically inhibited by antisense RNA. 1985, Pubmed , Xenbase
Harvey, Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos. 1988, Pubmed , Xenbase
Hatcher, TBX5 transcription factor regulates cell proliferation during cardiogenesis. 2001, Pubmed
Haworth, GATA4 and GATA5 are essential for heart and liver development in Xenopus embryos. 2008, Pubmed , Xenbase
Heasman, Beta-catenin signaling activity dissected in the early Xenopus embryo: a novel antisense approach. 2000, Pubmed , Xenbase
Hellsten, The genome of the Western clawed frog Xenopus tropicalis. 2010, Pubmed , Xenbase
Hilton, Left-sided embryonic expression of the BCL-6 corepressor, BCOR, is required for vertebrate laterality determination. 2007, Pubmed , Xenbase
Hirakow, Epicardial formation in staged human embryos. 1992, Pubmed
Hiroi, Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. 2001, Pubmed , Xenbase
Hjalt, Current molecular understanding of Axenfeld-Rieger syndrome. 2005, Pubmed
Ho, Formation of the epicardium studied with the scanning electron microscope. 1978, Pubmed
Hoffman, The incidence of congenital heart disease. 2002, Pubmed
Horb, Tbx5 is essential for heart development. 1999, Pubmed , Xenbase
Hurd, Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues. 2007, Pubmed
Iida, Essential roles of the winged helix transcription factor MFH-1 in aortic arch patterning and skeletogenesis. 1997, Pubmed
Inui, Xapelin and Xmsr are required for cardiovascular development in Xenopus laevis. 2006, Pubmed , Xenbase
Jacquier, An intron-encoded protein is active in a gene conversion process that spreads an intron into a mitochondrial gene. 1985, Pubmed
Jahr, Development of the proepicardium in Xenopus laevis. 2008, Pubmed , Xenbase
Jarvis, Sprouty proteins are in vivo targets of Corkscrew/SHP-2 tyrosine phosphatases. 2006, Pubmed
Jerome, DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. 2001, Pubmed
Jongmans, CHARGE syndrome: the phenotypic spectrum of mutations in the CHD7 gene. 2006, Pubmed
Kaliakatsos, Combined microdeletions and CHD7 mutation causing severe CHARGE/DiGeorge syndrome: clinical presentation and molecular investigation by array-CGH. 2010, Pubmed
Kawakami, Identification of a functional transposase of the Tol2 element, an Ac-like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineage. 2000, Pubmed
Kawakami, Excision of the Tol2 transposable element of the medaka fish Oryzias latipes in Xenopus laevis and Xenopus tropicalis. 2004, Pubmed , Xenbase
Kieserman, High-magnification in vivo imaging of Xenopus embryos for cell and developmental biology. 2010, Pubmed , Xenbase
Kirk, Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. 2007, Pubmed
Kitaguchi, Zic3 is involved in the left-right specification of the Xenopus embryo. 2000, Pubmed , Xenbase
Kitaguchi, Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry. 2002, Pubmed , Xenbase
Knudsen, Antisense properties of duplex- and triplex-forming PNAs. 1996, Pubmed
Kochilas, The role of neural crest during cardiac development in a mouse model of DiGeorge syndrome. 2002, Pubmed
Kochilas, Cloning and characterization of zebrafish tbx1. 2003, Pubmed
Kolker, Confocal imaging of early heart development in Xenopus laevis. 2000, Pubmed , Xenbase
Kosaki, PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome. 2002, Pubmed
Kratz, The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. 2005, Pubmed
Krebs, Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. 2003, Pubmed
Krenz, Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling. 2005, Pubmed
Kroll, Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation. 1996, Pubmed , Xenbase
Kumano, ADMP2 is essential for primitive blood and heart development in Xenopus. 2006, Pubmed , Xenbase
Kume, The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. 2001, Pubmed
Kuo, GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. 1997, Pubmed
Köster, Expression pattern of the winged helix factor XFD-11 during Xenopus embryogenesis. 1998, Pubmed , Xenbase
Lalani, Spectrum of CHD7 mutations in 110 individuals with CHARGE syndrome and genotype-phenotype correlation. 2006, Pubmed
Langdon, SHP-2 is required for the maintenance of cardiac progenitors. 2007, Pubmed , Xenbase
Latinkic, Transcriptional regulation of the cardiac-specific MLC2 gene during Xenopus embryonic development. 2004, Pubmed , Xenbase
Latinkić, Distinct enhancers regulate skeletal and cardiac muscle-specific expression programs of the cardiac alpha-actin gene in Xenopus embryos. 2002, Pubmed , Xenbase
Layman, Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome. 2009, Pubmed
Lee, The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. 1998, Pubmed
Lehner, Pedigree analysis and descriptive investigation of three classic phenotypes associated with Holt-Oram syndrome. 2003, Pubmed
Lepilina, A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. 2006, Pubmed
Li, Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family. 1997, Pubmed
Liberatore, Ventricular expression of tbx5 inhibits normal heart chamber development. 2000, Pubmed , Xenbase
Lie-Venema, Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development. 2007, Pubmed
Lie-Venema, Myocardial heterogeneity in permissiveness for epicardium-derived cells and endothelial precursor cells along the developing heart tube at the onset of coronary vascularization. 2005, Pubmed
Lin, Heterotaxy: associated conditions and hospital-based prevalence in newborns. 2000, Pubmed
Lin, Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis. 1999, Pubmed , Xenbase
Lindsay, Congenital heart disease in mice deficient for the DiGeorge syndrome region. 1999, Pubmed
Lindsay, Recovery from arterial growth delay reduces penetrance of cardiovascular defects in mice deleted for the DiGeorge syndrome region. 2001, Pubmed
Lindsay, Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. 2001, Pubmed
Liu, Pitx2c patterns anterior myocardium and aortic arch vessels and is required for local cell movement into atrioventricular cushions. 2002, Pubmed , Xenbase
Liu, T-box transcription factor TBX20 mutations in Chinese patients with congenital heart disease. 2008, Pubmed
Logan, Induction of cardiac muscle differentiation in isolated animal pole explants of Xenopus laevis embryos. 1993, Pubmed , Xenbase
Loh, PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group. 2004, Pubmed
Lu, Function of Rieger syndrome gene in left-right asymmetry and craniofacial development. 1999, Pubmed
Lyons, Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. 1995, Pubmed
Maclean, Axenfeld-Rieger malformation and distinctive facial features: Clues to a recognizable 6p25 microdeletion syndrome. 2005, Pubmed
Maheshwari, PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13. 2002, Pubmed
Mammi, Cardiovascular anomaly in Rieger Syndrome: heterogeneity or contiguity? 1998, Pubmed
Mandel, The BMP pathway acts to directly regulate Tbx20 in the developing heart. 2010, Pubmed , Xenbase
Mariampillai, Doppler optical cardiogram gated 2D color flow imaging at 1000 fps and 4D in vivo visualization of embryonic heart at 45 fps on a swept source OCT system. 2007, Pubmed , Xenbase
McDermott, TBX5 genetic testing validates strict clinical criteria for Holt-Oram syndrome. 2005, Pubmed
Melton, Injected anti-sense RNAs specifically block messenger RNA translation in vivo. 1985, Pubmed , Xenbase
Mercola, Embryological basis for cardiac left-right asymmetry. 1999, Pubmed , Xenbase
Merki, Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. 2005, Pubmed
Merscher, TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. 2001, Pubmed
Mohun, The morphology of heart development in Xenopus laevis. 2000, Pubmed , Xenbase
Molkentin, Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. 1997, Pubmed
Momma, Cardiovascular anomalies associated with chromosome 22q11.2 deletion syndrome. 2010, Pubmed
Moody, Fates of the blastomeres of the 32-cell-stage Xenopus embryo. 1987, Pubmed , Xenbase
Moore, YAC transgenic analysis reveals Wilms' tumour 1 gene activity in the proliferating coelomic epithelium, developing diaphragm and limb. 1998, Pubmed
Morcos, Achieving targeted and quantifiable alteration of mRNA splicing with Morpholino oligos. 2007, Pubmed
Moskowitz, The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system. 2004, Pubmed
Moulton, Using morpholinos to control gene expression. 2007, Pubmed
Movassagh, Cardiac differentiation in Xenopus requires the cyclin-dependent kinase inhibitor, p27Xic1. 2008, Pubmed , Xenbase
Musante, Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome. 2003, Pubmed
Männer, The anatomy of cardiac looping: a step towards the understanding of the morphogenesis of several forms of congenital cardiac malformations. 2009, Pubmed , Xenbase
Männer, Experimental analyses of the function of the proepicardium using a new microsurgical procedure to induce loss-of-proepicardial-function in chick embryos. 2005, Pubmed
Männer, Cardiac looping in the chick embryo: a morphological review with special reference to terminological and biomechanical aspects of the looping process. 2000, Pubmed
Männer, The origin, formation and developmental significance of the epicardium: a review. 2001, Pubmed
Nagao, HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus. 2008, Pubmed , Xenbase
Newbury-Ecob, Holt-Oram syndrome: a clinical genetic study. 1996, Pubmed
Noonan, Noonan syndrome. An update and review for the primary pediatrician. 1994, Pubmed
Noonan, Hypertelorism with Turner phenotype. A new syndrome with associated congenital heart disease. 1968, Pubmed
Ogino, Highly efficient transgenesis in Xenopus tropicalis using I-SceI meganuclease. 2006, Pubmed , Xenbase
Pan, I-SceI meganuclease-mediated transgenesis in Xenopus. 2006, Pubmed , Xenbase
Pandur, Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. 2002, Pubmed , Xenbase
Parinov, Tol2 transposon-mediated enhancer trap to identify developmentally regulated zebrafish genes in vivo. 2004, Pubmed
Pehlivan, GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease. 1999, Pubmed
Peterkin, Redundancy and evolution of GATA factor requirements in development of the myocardium. 2007, Pubmed , Xenbase
Plageman, Differential expression and function of Tbx5 and Tbx20 in cardiac development. 2004, Pubmed
Pombal, Epicardial development in lamprey supports an evolutionary origin of the vertebrate epicardium from an ancestral pronephric external glomerulus. 2008, Pubmed
Posch, A gain-of-function TBX20 mutation causes congenital atrial septal defects, patent foramen ovale and cardiac valve defects. 2010, Pubmed
Purandare, A complex syndrome of left-right axis, central nervous system and axial skeleton defects in Zic3 mutant mice. 2002, Pubmed
Pérez-Pomares, Experimental studies on the spatiotemporal expression of WT1 and RALDH2 in the embryonic avian heart: a model for the regulation of myocardial and valvuloseptal development by epicardially derived cells (EPDCs). 2002, Pubmed
Qian, Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. 2008, Pubmed
Qu, The SHP-2 tyrosine phosphatase: signaling mechanisms and biological functions. 2000, Pubmed
Raffin, Subdivision of the cardiac Nkx2.5 expression domain into myogenic and nonmyogenic compartments. 2000, Pubmed , Xenbase
Ramsdell, Left-right lineage analysis of the embryonic Xenopus heart reveals a novel framework linking congenital cardiac defects and laterality disease. 2006, Pubmed , Xenbase
Raya, Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos. 2003, Pubmed
Rusconi, Transformation of frog embryos with a rabbit beta-globin gene. 1981, Pubmed , Xenbase
Ryan, Pitx2 determines left-right asymmetry of internal organs in vertebrates. 1998, Pubmed , Xenbase
Sauka-Spengler, Embryonic expression of Tbx1, a DiGeorge syndrome candidate gene, in the lamprey Lampetra fluviatilis. 2002, Pubmed
Sauka-Spengler, A gene regulatory network orchestrates neural crest formation. 2008, Pubmed
Saxton, Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2. 1997, Pubmed
Saxton, Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2. 1999, Pubmed
Schneider, Wnt antagonism initiates cardiogenesis in Xenopus laevis. 2001, Pubmed , Xenbase
Schott, Congenital heart disease caused by mutations in the transcription factor NKX2-5. 1998, Pubmed , Xenbase
Schweickert, Pitx2 isoforms: involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry. 2000, Pubmed , Xenbase
Seo, The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development. 2006, Pubmed , Xenbase
Seo, Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract. 2006, Pubmed
Sepulveda, GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. 1998, Pubmed , Xenbase
Serluca, Development of the proepicardial organ in the zebrafish. 2008, Pubmed
Showell, Decoding development in Xenopus tropicalis. 2007, Pubmed , Xenbase
Showell, Developmental expression patterns of Tbx1, Tbx2, Tbx5, and Tbx20 in Xenopus tropicalis. 2006, Pubmed , Xenbase
Siebert, Pathologic features of the CHARGE association: support for involvement of the neural crest. 1985, Pubmed
Singh, Tbx20 is essential for cardiac chamber differentiation and repression of Tbx2. 2005, Pubmed
Sinzelle, Generation of trangenic Xenopus laevis using the Sleeping Beauty transposon system. 2006, Pubmed , Xenbase
Sletten, Variation in severity of cardiac disease in Holt-Oram syndrome. 1996, Pubmed
Small, Transgenic analysis of the atrialnatriuretic factor (ANF) promoter: Nkx2-5 and GATA-4 binding sites are required for atrial specific expression of ANF. 2003, Pubmed , Xenbase
Small, Myocardin is sufficient and necessary for cardiac gene expression in Xenopus. 2005, Pubmed , Xenbase
Smith, Xenopus laevis transgenesis by sperm nuclear injection. 2006, Pubmed , Xenbase
Smith, The MLC1v gene provides a transgenic marker of myocardium formation within developing chambers of the Xenopus heart. 2005, Pubmed , Xenbase
Sparrow, Regulation of the tinman homologues in Xenopus embryos. 2000, Pubmed , Xenbase
Starr, Tetralogy of fallot: yesterday and today. 2010, Pubmed
Stennard, Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. 2003, Pubmed , Xenbase
Stennard, Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. 2005, Pubmed
Sucov, Epicardial control of myocardial proliferation and morphogenesis. 2009, Pubmed
Summerton, Morpholino, siRNA, and S-DNA compared: impact of structure and mechanism of action on off-target effects and sequence specificity. 2007, Pubmed
Sutherland, Disorders of left-right asymmetry: heterotaxy and situs inversus. 2009, Pubmed
Svensson, A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription. 2000, Pubmed
Swiderski, Expression of the Mf1 gene in developing mouse hearts: implication in the development of human congenital heart defects. 1999, Pubmed
Szeto, HrT is required for cardiovascular development in zebrafish. 2002, Pubmed
Sznajer, The spectrum of cardiac anomalies in Noonan syndrome as a result of mutations in the PTPN11 gene. 2007, Pubmed
Tabin, A two-cilia model for vertebrate left-right axis specification. 2003, Pubmed
Takeuchi, Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. 2005, Pubmed
Tang, The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. 1995, Pubmed , Xenbase
Tartaglia, Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia. 2003, Pubmed
Tartaglia, PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity. 2002, Pubmed
Tartaglia, Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. 2001, Pubmed
Tevosian, FOG-2, a cofactor for GATA transcription factors, is essential for heart morphogenesis and development of coronary vessels from epicardium. 2000, Pubmed
Toyoizumi, Subtilisin-like proprotein convertase activity is necessary for left-right axis determination in Xenopus neurula embryos. 2006, Pubmed , Xenbase
Van Vactor, Genetic analysis of protein tyrosine phosphatases. 1998, Pubmed
Virágh, The origin of the epicardium and the embryonic myocardial circulation in the mouse. 1981, Pubmed
Vissers, Mutations in a new member of the chromodomain gene family cause CHARGE syndrome. 2004, Pubmed
Vitelli, A genetic link between Tbx1 and fibroblast growth factor signaling. 2002, Pubmed
Waldo, Conotruncal myocardium arises from a secondary heart field. 2001, Pubmed , Xenbase
Ware, Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects. 2004, Pubmed , Xenbase
Warkman, Xenopus as a model system for vertebrate heart development. 2007, Pubmed , Xenbase
Weisschuh, A novel mutation in the FOXC1 gene in a family with Axenfeld-Rieger syndrome and Peters' anomaly. 2008, Pubmed
Wessels, Novel CHD7 mutations contributing to the mutation spectrum in patients with CHARGE syndrome. 2010, Pubmed
Wincent, CHD7 mutation spectrum in 28 Swedish patients diagnosed with CHARGE syndrome. 2008, Pubmed
Winnier, Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. 1999, Pubmed
Winter, Epicardium-derived cells in cardiogenesis and cardiac regeneration. 2007, Pubmed
Winter, Preservation of left ventricular function and attenuation of remodeling after transplantation of human epicardium-derived cells into the infarcted mouse heart. 2007, Pubmed
Winter, A new direction for cardiac regeneration therapy: application of synergistically acting epicardium-derived cells and cardiomyocyte progenitor cells. 2009, Pubmed
Xu, Distribution of polymorphic and non-polymorphic microsatellite repeats in Xenopus tropicalis. 2008, Pubmed , Xenbase
Xu, Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. 2004, Pubmed
Yagi, Role of TBX1 in human del22q11.2 syndrome. 2003, Pubmed
Yamagishi, Unraveling the genetic and developmental mysteries of 22q11 deletion syndrome. 2003, Pubmed
Yang, An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival. 2006, Pubmed
Yelin, Multimodality optical imaging of embryonic heart microstructure. 2007, Pubmed , Xenbase
Yergeau, Manipulating the Xenopus genome with transposable elements. 2007, Pubmed , Xenbase
Yergeau, Transgenesis in Xenopus using the Sleeping Beauty transposon system. 2009, Pubmed , Xenbase
Zhang, SOX7 and SOX18 are essential for cardiogenesis in Xenopus. 2005, Pubmed , Xenbase
Zhang, Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. 2000, Pubmed
Zhou, Genetic fate mapping demonstrates contribution of epicardium-derived cells to the annulus fibrosis of the mammalian heart. 2010, Pubmed
Zhou, Post-transcriptional suppression of gene expression in Xenopus embryos by small interfering RNA. 2002, Pubmed , Xenbase