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???displayArticle.abstract??? Kidney development is a paradigm of how multiple cell types are integrated into highly specialized epithelial structures via various inductive events. A network of transcription factors and signaling pathways have been identified as crucial regulators. The recent discovery of a group of small, non-coding RNAs, microRNAs (miRNAs), has added a new layer of complexity. Studies using the pronephric kidney of Xenopus and the metanephric kidney of mouse have demonstrated that a tight regulation of mRNA stability and translation efficiency by miRNAs is very important as well. The interplay between miRNAs and the transcriptional network provides plasticity and robustness to the system. Importantly, miRNAs are not only necessary for early aspects of kidney development, but also later in life. As such they may provide a mean to maintain/modulate kidney function during homeostasis and injury.
Agrawal,
The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1.
2009, Pubmed,
Xenbase
Agrawal,
The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription factor Xlim1/Lhx1.
2009,
Pubmed
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Xenbase Bartel,
MicroRNAs: target recognition and regulatory functions.
2009,
Pubmed Boutet,
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney.
2006,
Pubmed Brodersen,
Revisiting the principles of microRNA target recognition and mode of action.
2009,
Pubmed Cano,
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2008,
Pubmed Carthew,
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2009,
Pubmed Chan,
A role for Xlim-1 in pronephros development in Xenopus laevis.
2000,
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Xenbase Dressler,
The cellular basis of kidney development.
2006,
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Xenbase Drummond,
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2005,
Pubmed Farh,
The widespread impact of mammalian MicroRNAs on mRNA repression and evolution.
2005,
Pubmed Harvey,
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2008,
Pubmed Ho,
Podocyte-specific loss of functional microRNAs leads to rapid glomerular and tubular injury.
2008,
Pubmed Jones,
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2005,
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Xenbase Kato,
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2007,
Pubmed Kobayashi,
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2005,
Pubmed
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Xenbase Liu,
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2006,
Pubmed Machuca,
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Pubmed Møbjerg,
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2000,
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Xenbase Raciti,
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Xenbase Shawlot,
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Pubmed Shi,
Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis.
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Pubmed Stark,
Animal MicroRNAs confer robustness to gene expression and have a significant impact on 3'UTR evolution.
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Pubmed Sun,
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Pubmed Torres,
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Pubmed Wang,
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Pubmed Zhou,
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2004,
Pubmed
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Xenbase
