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Xenopus, from basic biology to disease models in the genomic era

Available for Download, Read Online, or purchase.


Edited by Abraham Fainsood and Sally A. Moody

ISBN: 978-0367505271

From the first description of Xenopus, through its contribution to biological principles, developmental processes, signaling pathways, to desease models and its use as a genetic model, including the implementation of modern "omic" approaches and gene editing

Table of Contents

Preface: Abraham Fainsod and Sally A. Moody

Section I: Contributions to Cell, Developmental and Molecular Biology

Chapter 1: A quick history of Xenopus: “The humble batrachian” - John B. Wallingford
Chapter 2: The study of cell division control and DNA replication in Xenopus egg extracts – Allison M. Jevitt and Susannah Rankin
Chapter 3: Maternal mRNAs and the making of cell lineages in the early Xenopus embryo - Douglas W. Houston
Chapter 4: Signaling components in dorsal-ventral patterning and the Organizer in Xenopus - Eddy M. De Robertis and Nydia Tejeda-Munoz
Chapter 5: Signaling pathways in anterior-posterior patterning - Chenbei Chang
Chapter 6: Wnt signaling in tissue differentiation and morphogenesis - Stefan Hoppler and Michael Kühl
Chapter 7: Multiple functions of Notch signaling during early embryogenesis - Silvia L. López
Chapter 8: The development and evolution of the vertebrate neural crest: insights from Xenopus – Joshua R. York and Carole LaBonne
Chapter 9: Ataulfo Martinez-Torres and Elizabeth Pereida-Jaramillo

Section II: Systems Biology and the Genomic Era

Chapter 10: The continuing evolution of the Xenopus genome - Mariko Kondo and Masanori Taira
Chapter 11: Dynamics of chromatin remodeling during Xenopus development - Gert Jan C. Veenstra
Chapter 12: Gene regulatory networks controlling Xenopus embryogenesis - Ken W. Y. Cho and Ira L. Blitz
Chapter 13: Development of high-resolution proteomic analyses in Xenopus - Elizabeth Van Itallie and Leonid Peshkin
Chapter 14: Advances in genome editing tools: Marko E. Horb, Anita Abu-Daya, Marcin Wlizla, Anna Noble, and Matt Guille

Section III: From Basic Biological Insights to Human Disease

Chapter 15: Formation of the left-right axis: insights from the Xenopus model – Axel Schweickert and Tim Ott
Chapter 16: Discovering the function of congenital heart disease genes - Delfina P. Gonzalez and Mustafa K. Khokha
Chapter 17: Craniofacial development and disorders: contributions of Xenopus - Ashwin Lokapally and Hazel Sive
Chapter 18: Modeling digestive and respiratory system development and disease in Xenopus - Scott A. Rankin and Aaron M. Zorn
Chapter 19: Functional neurobiology in Xenopus provides insights into health and disease – Clayton Gordy, Michael Forsthofer, Parthena Soupiadou, Suzan Ozugur and Hans Straka
Chapter 20: Leaping towards the understanding of spinal cord regeneration - Paula Slater, Gabriela Edwards-Faret and Juan Larrain
Chapter 21: Studying tumor formation and regulation in Xenopus – Dieter Tulkens and Kris Vleminckx Chapter 22: Xenopus: a model to study natural genetic variation and its disease implications - Avi Leibovich, Sally A. Moody, Steven L. Klein and Abraham Fainsod
Chapter 23: Using Xenopus to understand pluripotency and reprogram cells for therapeutic use – Meghana S. Oak and Eva Hörmanseder


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Last Updated: 2021-07-19